BDBM50274118 CHEMBL4127030::US10793591, Compound 7a

SMILES C[C@@]1(O)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O

InChI Key InChIKey=YEFGXGBFIOVTEX-MVHNUAHISA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50274118   

TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274118(CHEMBL4127030 | US10793591, Compound 7a)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1973-2419](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

US Patent
LigandPNGBDBM50274118(CHEMBL4127030 | US10793591, Compound 7a)
Affinity DataIC50: <1.00E+3nMAssay Description:The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein [1973-2419](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

US Patent
LigandPNGBDBM50274118(CHEMBL4127030 | US10793591, Compound 7a)
Affinity DataIC50: <1.00E+3nMAssay Description:The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50274118(CHEMBL4127030 | US10793591, Compound 7a)
Affinity DataIC50:  140nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed