BDBM50303420 6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-carbonitrile::6-[(3,5-difluorophenyl)amino]-9-ethyl-9H-purine-2-carbonitrile::CHEMBL567341

SMILES CCn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N

InChI Key InChIKey=SZYYBVWPURUFRR-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50303420   

TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 15 minsMore data for this Ligand-Target Pair
TargetKallikrein-4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of human Kallikrein 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase K(Engyodontium album)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  7.41E+4nMAssay Description:Inhibition of human Proteinase KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  44.7nMAssay Description:Inhibition of papaya papainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  34.7nMAssay Description:Inhibition of human Cathepsin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin Z(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  933nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  7.24E+4nMAssay Description:Inhibition of human MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  7.41E+4nMAssay Description:Inhibition of human TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-4(Homo sapiens (Human))
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  3.31E+4nMAssay Description:Inhibition of human Caspase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed