BDBM50304950 CHEMBL589404::N-(2-(3-fluorophenyl)-2-hydroxyethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide

SMILES Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1cccc(F)c1

InChI Key InChIKey=GTXTVLCIXHWSIV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50304950   

TargetAcyl-CoA desaturase 1(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304950(CHEMBL589404 | N-(2-(3-fluorophenyl)-2-hydroxyethy...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Scd1 in mouse liver microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304950(CHEMBL589404 | N-(2-(3-fluorophenyl)-2-hydroxyethy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Scd1 expressed in HEK-293A cells assessed as conversion of [14C]stearate to [14C]oleate pretreated for 30 mins measured after 4 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50304950(CHEMBL589404 | N-(2-(3-fluorophenyl)-2-hydroxyethy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Scd1 in human HEK-293A cell microsomes assessed as conversion of [14C]stearate to [14C]oleate pretreated for 10 mins measured after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed