BDBM50321655 3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine::CHEMBL1170126

SMILES c1n[nH]cc1-c1cn2c(cnc2cn1)-c1c[nH]c2ccccc12

InChI Key InChIKey=ZCWUDZOATSSBCE-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50321655   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321655(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of CHK1 by DELFIAMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321655(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Affinity DataIC50:  1.55E+8nMAssay Description:Inhibition of CHK1 (unknown origin) assessed as inhibition of CDC25 phosphorylation after 30 min by DELFIA assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321655(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of GSK3-beta at 10 uM by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50321655(3-(1H-indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed