BDBM50325537 CHEMBL1224310::CHEMBL1229095::S-(2-Chlorobenzyl)isothiourea hydrochloride::cid_199161

SMILES NC(=N)SCc1ccccc1Cl

InChI Key InChIKey=SFKYKNIIEFCNBX-UHFFFAOYSA-N

Data  5 IC50  4 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50325537   

TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataEC50:  2.26E+3nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHeat shock factor protein 1(Mus musculus)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataEC50:  1.21E+5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGuanine nucleotide-binding protein subunit alpha-15(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataEC50: >2.99E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataIC50:  5.21E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGuanine nucleotide-binding protein subunit alpha-15(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataIC50: >2.99E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of IDO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of indoleamine-2,3-dioxygenase in human A431 cells assessed as inhibition of IFN-gamma-stimulated kynurenine productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50325537(CHEMBL1224310 | CHEMBL1229095 | S-(2-Chlorobenzyl)...)
Affinity DataEC50:  1.42E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay