BDBM50359075 CHEMBL1922655
SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cc(ccn4)C(F)(F)F)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1
InChI Key InChIKey=GXYBYLNYVQUPKN-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50359075
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by ChEMBL
Amira Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 452nMAssay Description:Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISAMore data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by ChEMBL
Amira Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of COX1-mediated TXB2 production in human whole blood after 30 mins by competitive enzyme immunoassayMore data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by ChEMBL
Amira Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISAMore data for this Ligand-Target Pair