BDBM50359523 CHEMBL1927147

SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccc4)Cc3c2c1=O

InChI Key InChIKey=DISVMXDWAMMVLT-UHFFFAOYSA-N

Data  5 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50359523   

TargetNADPH oxidase 4(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataKi:  72nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADPH oxidase 1(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataKi:  101nMAssay Description:Antagonist activity at human NOX1 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNADPH oxidase 5(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataKi:  414nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b-245 heavy chain(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataKi:  1.34E+3nMAssay Description:Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of xanthine oxidase assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human recombinant CYP2D6 by mass spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human recombinant CYP2C19 by mass spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human recombinant CYP2C9 by mass spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human recombinant CYP1A2 assessed as inhibition of fluorescent metabolite formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genkyotex

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human recombinant CYP3A4 by mass spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed