BDBM50379157 CHEMBL1234899::US8703811, 57
SMILES Cc1nc2cc(OC(F)(F)F)ccc2n1-c1ccc(s1)C(=O)NC1CC1
InChI Key InChIKey=ACFOZQUWTKSSQQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50379157
Affinity DataIC50: 64nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (30 to 396 residues) expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate after 20...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP2D6 using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair