BDBM50384774 CHEMBL1917204::US20230414581, Compound 6

SMILES Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O

InChI Key InChIKey=QUIIIYITNGOFEI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50384774   

TargetRegulator of G-protein signaling 4(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM50384774(CHEMBL1917204 | US20230414581, Compound 6)
Affinity DataIC50:  30nMAssay Description:FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRegulator of G-protein signaling 8(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM50384774(CHEMBL1917204 | US20230414581, Compound 6)
Affinity DataIC50:  1.10E+4nMAssay Description:FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRegulator of G-protein signaling 16(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM50384774(CHEMBL1917204 | US20230414581, Compound 6)
Affinity DataIC50:  3.50E+3nMAssay Description:FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNAD(+) hydrolase SARM1(Homo sapiens)
Artivila Biopharma

US Patent
LigandPNGBDBM50384774(CHEMBL1917204 | US20230414581, Compound 6)
Affinity DataIC50: <1.00E+3nMAssay Description:First, 200 μM of the compound was added to a 50 mM Tris-HCl (pH 7.5) solution containing 0.05 μg/ml dN-SARM1. Then half of the mixture was ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRegulator of G-protein signaling 8(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM50384774(CHEMBL1917204 | US20230414581, Compound 6)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of RGS8 interaction with Galpha0 protein by flow cytometry protein interaction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRegulator of G-protein signaling 4(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM50384774(CHEMBL1917204 | US20230414581, Compound 6)
Affinity DataIC50:  30nMAssay Description:Inhibition of RGS4 interaction with Galpha0 protein by flow cytometry protein interaction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRegulator of G-protein signaling 19(Homo sapiens (Human))
University Of Michigan

US Patent
LigandPNGBDBM50384774(CHEMBL1917204 | US20230414581, Compound 6)
Affinity DataIC50:  120nMAssay Description:FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...More data for this Ligand-Target Pair
In DepthDetails US Patent