BDBM50398608 MARIZOMIB

SMILES C[C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2CCCl)[C@@H](O)[C@H]1CCCC=C1

InChI Key InChIKey=NGWSFRIPKNWYAO-SHTIJGAHSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50398608   

TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50:  22nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50:  430nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50:  28nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta2 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of 20S proteasome (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-1(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50:  0.604nMAssay Description:Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50: >11nMAssay Description:Inhibition of 20S proteasome beta 2c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50:  3.5nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta5 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed