BDBM50426994 CHEMBL2326533
SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O
InChI Key InChIKey=CYXJGNUHXUIEQM-MOAULALOSA-N
Data 27 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50426994
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of chymotrypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 20S immunoproteasome beta 1 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of caspase-like activity of proteasome in human NCI-H929 cells at 200 uM after 6 hrs by proteasomeGlo assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of chymotrypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of trypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Competitive inhibition of caspase-like activity of proteasome beta 1 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Competitive inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BO...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Competitive inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of caspase-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human 20S constitutive proteasome beta-5 using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human 20S immunoproteasome beta-5 using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human 20S constitutive proteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue sta...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome beta 1 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of 20S constitutive proteasome beta 5 chymotrypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of 20S immunoproteasome beta 5 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 20S constitutive proteasome beta 1 caspase-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome beta 5 in human RPMI8226 cell lysates after 1 hr by coomassie brilliant blue staining-based fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of trypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assayMore data for this Ligand-Target Pair