BDBM50460939 CHEMBL4228654

SMILES CC(C)Nc1ccc2cnn(-c3cncc(n3)-c3ccc(cc3)C(O)=O)c2c1

InChI Key InChIKey=RJXWGPDMMDILGJ-UHFFFAOYSA-N

Data  15 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50460939   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  54nMAssay Description:Inhibition of DYRK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: <3nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  120nMAssay Description:Inhibition of human PIM1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHomeodomain-interacting protein kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: <3nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  260nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human PIM2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  110nMAssay Description:Inhibition of CK2alpha in human HCT116 or human DLD1 cells assessed as decrease in AKT phosphorylation at S129 residue after 3 to 24 hrs by Western b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  7nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50:  360nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed