BDBM50491728 CHEMBL2385557::US10865384, Compound IM-4

SMILES Cc1cccc(c1)-c1nc([nH]c1-c1ccncc1)-c1ccc2ccccc2c1F

InChI Key InChIKey=FSSVIZLKIGCSBI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50491728   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50491728(CHEMBL2385557 | US10865384, Compound IM-4)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant GST-tagged p38alpha MAP kinase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences

Curated by ChEMBL
LigandPNGBDBM50491728(CHEMBL2385557 | US10865384, Compound IM-4)
Affinity DataIC50:  20nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM50491728(CHEMBL2385557 | US10865384, Compound IM-4)
Affinity DataIC50:  277nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM50491728(CHEMBL2385557 | US10865384, Compound IM-4)
Affinity DataIC50:  277nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM50491728(CHEMBL2385557 | US10865384, Compound IM-4)
Affinity DataIC50:  490nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Agency For Science, Technology And Research

US Patent
LigandPNGBDBM50491728(CHEMBL2385557 | US10865384, Compound IM-4)
Affinity DataIC50:  490nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter™ p38 MAP kinase binding assay from ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent