BDBM50511658 Cb-1158::INCB-001158::Incb 001158::Incb001158::Numidargistat

SMILES C[C@H](N)C(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O

InChI Key InChIKey=ZZJLMZYUGLJBSO-LAEOZQHASA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50511658   

TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant human arginase 1 using L-arginine as substrate measured after 60 mins in presence of manganese chloride by o-phthaldialdehy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  98nMAssay Description:Inhibition of human arginase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  86nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  296nMMore data for this Ligand-Target Pair
In DepthDetails
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  29nMMore data for this Ligand-Target Pair
In DepthDetails
TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  296nMMore data for this Ligand-Target Pair
In DepthDetails
TargetArginase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  86nMMore data for this Ligand-Target Pair
In DepthDetails
TargetArginase-2, mitochondrial(Homo sapiens (Human))TBA
LigandPNGBDBM50511658(Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 |...)
Affinity DataIC50:  296nMAssay Description:Inhibition of human Arg2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed