BDBM50519597 CHEMBL4522012

SMILES Cc1cc(NC2CCN(C)CC2)ccc1-c1cc2c(N3CCC[C@H](C(=O)NCc4ccc(OC(F)(F)F)cc4)C3)ncnc2[nH]1

InChI Key InChIKey=PRUWBPAGUCKXMV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50519597   

TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519597BDBM50519597(CHEMBL4522012)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of ALK (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519597BDBM50519597(CHEMBL4522012)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ALK R1275Q mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519597BDBM50519597(CHEMBL4522012)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of ALK C1156Y mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519597BDBM50519597(CHEMBL4522012)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519597BDBM50519597(CHEMBL4522012)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of ALK F1174L mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50519597BDBM50519597(CHEMBL4522012)
Affinity DataIC50: 434nMAssay Description:Inhibition of IGF1R (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed