BDBM50521251 CHEMBL4443236

SMILES [H][C@@]12CN(CCN1c1nc(nc3cc(c(Cl)c(OC2)c13)-c1c(C)ccc2[nH]ncc12)N1CC(C1)N(C)C)C(=O)C=C

InChI Key InChIKey=FKHASWQIAUADON-SFHVURJKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521251   

TargetGTPase KRas(Homo sapiens (Human))
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50521251(CHEMBL4443236)
Affinity DataIC50:  21nMAssay Description:Inhibition of GDP loaded biotin-labeled KRAS G12C mutant (unknown origin) assessed as reduction in guanine nucleotide exchange preincubated for 4 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50521251(CHEMBL4443236)
Affinity DataIC50:  21nMAssay Description:Inhibition of GDP loaded biotin-labeled KRAS G12C mutant (unknown origin) assessed as reduction in guanine nucleotide exchange preincubated for 4 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed