BDBM50565819 CHEMBL4794168

SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O

InChI Key InChIKey=GJFLVESIDOAAJH-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50565819   

TargetMelanocortin receptor 4(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565819BDBM50565819(CHEMBL4794168)
Affinity DataKi:  0.0158nMAssay Description:Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC4R expressed in HEK293 cell membranes incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565819BDBM50565819(CHEMBL4794168)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC4R expressed in HEK293 cell membranes incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565819BDBM50565819(CHEMBL4794168)
Affinity DataKi:  0.135nMAssay Description:Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565819BDBM50565819(CHEMBL4794168)
Affinity DataKi:  0.135nMAssay Description:Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565819BDBM50565819(CHEMBL4794168)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human MC4R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565819BDBM50565819(CHEMBL4794168)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human MC4R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565819BDBM50565819(CHEMBL4794168)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565819BDBM50565819(CHEMBL4794168)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed