BDBM98891 US8497265, 217::US8497265, 239

SMILES OCC1CCN(CC1)c1nccnc1OC1CN(C1)c1ccc2ccccc2n1

InChI Key InChIKey=VIXNRMUNIQTMQR-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 98891   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  2.30nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Amgen

US Patent
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  23.3nMAssay Description:Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif). More data for this Ligand-Target Pair
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human PDE10A using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human PDE10A2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE11A4 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  8.04E+3nMAssay Description:Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE9A2 using FAM-cGMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of human PDE4D2 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE5A using FAM-cGMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE7A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human PDE8A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM98891(US8497265, 217 | US8497265, 239)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of human PDE2A1 using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed