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Found 101 with Last Name = 'altieri' and Initial = 'a'
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50: <500nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase by colorimetric assayMore data for this Ligand-Target Pair
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573607(CHEMBL4870333)
Affinity DataIC50:  800nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50:  900nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in channel current at -80 mV holding potential by whole-cell patch clamp me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573611(CHEMBL4865734)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in channel current at -80 mV holding potential by whole-cell patch clamp me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573606(CHEMBL4855389)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573608(CHEMBL4857342)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573610(CHEMBL4873946)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573609(CHEMBL4862383)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573628(CHEMBL4872465)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573629(CHEMBL4877716)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573613(CHEMBL4873037)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573611(CHEMBL4865734)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573612(CHEMBL4863284)
Affinity DataIC50:  1.24E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573621(CHEMBL4878198)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573620(CHEMBL4874263)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573619(CHEMBL4850793)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573618(CHEMBL4861937)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573600(CHEMBL4865098)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573601(CHEMBL4864087)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573602(CHEMBL4861854)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573603(CHEMBL4878945)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573607(CHEMBL4870333)
Affinity DataIC50:  1.89E+4nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in channel current at -80 mV holding potential by whole-cell patch clamp me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573604(CHEMBL4879341)
Affinity DataIC50: >2.34E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Moscow State University

Curated by ChEMBL
LigandPNGBDBM50573605(CHEMBL4867275)
Affinity DataIC50: >2.34E+4nMAssay Description:Inhibition of gp120 in HIV-1 subtype B #11578 harboring pseudotyped Env pWEAUd15.410.5017 infected in human TZM-bl cells assessed as reduction in vir...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50237224(CHEMBL4083672)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236717(CHEMBL4096918)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50237224(CHEMBL4083672)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50237125(CHEMBL4075766)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236717(CHEMBL4096918)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50237125(CHEMBL4075766)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50237125(CHEMBL4075766)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50237125(CHEMBL4075766)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236717(CHEMBL4096918)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50237224(CHEMBL4083672)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50237224(CHEMBL4083672)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Lindsey F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236717(CHEMBL4096918)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 60 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2B6 using bupropion as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2B6 using bupropion as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2B6 using bupropion as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C8 using paclitaxel as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C8 using paclitaxel as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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