BindingDB PrimarySearch_ki

Found 111 with Last Name = 'kamiguchi' and Initial = 'n'

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50129260(CHEMBL3629735)

IC50: 0.0800nMAssay Description:Inhibition of human PDE10A2 expressed in COS-7 cells using [3H]cGMP as substrate assessed as substrate hydrolysis after 60 mins by scintillation prox...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50129262(CHEMBL3627741)

IC50: 0.110nMAssay Description:Inhibition of human PDE10A2 expressed in COS-7 cells using [3H]cGMP as substrate assessed as substrate hydrolysis after 60 mins by scintillation prox...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50129261(CHEMBL3629734)

IC50: 0.120nMAssay Description:Inhibition of human PDE10A2 expressed in COS-7 cells using [3H]cGMP as substrate assessed as substrate hydrolysis after 60 mins by scintillation prox...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50129263(CHEMBL3629733)

IC50: 0.130nMAssay Description:Inhibition of human PDE10A2 expressed in COS-7 cells using [3H]cGMP as substrate assessed as substrate hydrolysis after 60 mins by scintillation prox...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50129264(CHEMBL3629732)

IC50: 0.220nMAssay Description:Inhibition of human PDE10A2 expressed in COS-7 cells using [3H]cGMP as substrate assessed as substrate hydrolysis after 60 mins by scintillation prox...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50129265(CHEMBL3629542)

IC50: 0.230nMAssay Description:Inhibition of human PDE10A2 expressed in COS-7 cells using [3H]cGMP as substrate assessed as substrate hydrolysis after 60 mins by scintillation prox...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258896(CHEMBL4060569 | US11419874, TAK-915)

IC50: 0.610nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50129266(CHEMBL3629541)

IC50: 0.790nMAssay Description:Inhibition of human PDE10A2 expressed in COS-7 cells using [3H]cGMP as substrate assessed as substrate hydrolysis after 60 mins by scintillation prox...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)

IC50: 0.860nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50129267(CHEMBL3629540)

IC50: 0.940nMAssay Description:Inhibition of human PDE10A2 expressed in COS-7 cells using [3H]cGMP as substrate assessed as substrate hydrolysis after 60 mins by scintillation prox...More data for this Ligand-Target Pair

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3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM107767(US11419874, PF-05180999 | US8598155, 2)

IC50: 1nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM107767(US11419874, PF-05180999 | US8598155, 2)

IC50: 1nMAssay Description:Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258930(CHEMBL4102321)

IC50: 1.60nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258926(CHEMBL4064402)

IC50: 2.80nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258929(CHEMBL4072982)

IC50: 3.5nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)

IC50: 4.70nMAssay Description:Inhibition of PDE2A (unknown origin) using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258894(CHEMBL4067117)

IC50: 7.20nMAssay Description:Inhibition of human N-terminal GST/C-terminal His-tagged PDE7B (109 to end residues) expressed in baculovirus infected fall armyworm Sf9 cells using ...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258894(CHEMBL4067117)

IC50: 7.20nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258923(CHEMBL4085207)

IC50: 8.70nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50026821(CHEMBL3331521 | US11419874, Example 10 | US9669035...)

IC50: 10nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258932(CHEMBL4098223)

IC50: 19nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258899(CHEMBL4079459)

IC50: 21nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258268(CHEMBL4059831 | US11419874, Example 21)

IC50: 24nMAssay Description:Inhibition of full length recombinant human His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258933(CHEMBL4068452)

IC50: 24nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258921(CHEMBL4097310)

IC50: 29nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258925(CHEMBL4093680)

IC50: 33nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258922(CHEMBL4082199)

IC50: 40nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258912(CHEMBL4078948)

IC50: 42nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258266(CHEMBL4088107)

IC50: 53nMAssay Description:Inhibition of full length recombinant human His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258266(CHEMBL4088107)

IC50: 53nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258914(CHEMBL4081720)

IC50: 62nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258919(CHEMBL4089589)

IC50: 65nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258902(CHEMBL4073981)

IC50: 72nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258927(CHEMBL4085934)

IC50: 77nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258898(CHEMBL4064344)

IC50: 78nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258898(CHEMBL4064344)

IC50: 78nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258904(CHEMBL4094525)

IC50: 80nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258924(CHEMBL4063592)

IC50: 85nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258913(CHEMBL4071171)

IC50: 210nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258918(CHEMBL4059794)

IC50: 250nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258897(CHEMBL4087340)

IC50: 480nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258301(CHEMBL4104510)

IC50: 490nMAssay Description:Inhibition of full length recombinant human His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258905(CHEMBL4084307)

IC50: 500nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258935(CHEMBL4072924)

IC50: 610nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258895(CHEMBL4082451)

IC50: 910nMAssay Description:Inhibition of recombinant human full-length His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258303(CHEMBL4064136)

IC50: 1.00E+3nMAssay Description:Inhibition of full length recombinant human His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258307(CHEMBL4085701)

IC50: 1.40E+3nMAssay Description:Inhibition of full length recombinant human His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258306(CHEMBL4094364)

IC50: 2.20E+3nMAssay Description:Inhibition of full length recombinant human His-tagged PDE2A3 expressed in fall armyworm Sf9 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258896(CHEMBL4060569 | US11419874, TAK-915)

IC50: 2.50E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged PDE1A expressed in baculovirus infected fall armyworm Sf9 cells using [3H]cGMP as s...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50258898(CHEMBL4064344)

IC50: 3.20E+3nMAssay Description:Inhibition of recombinant human PDE6A/PDE6B expressed in insect cells using [3H]cGMP as substrate preincubated for 30 mins followed by substrate addi...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Targets 11▿
- cGMP-dependent 3',5'-cyclic phosphodiesterase 64
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 12
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 4
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 4
- cAMP-specific 3',5'-cyclic phosphodiesterase 7B 4
- cGMP-specific 3',5'-cyclic phosphodiesterase 4
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 4
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 4
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 4
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 4
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta 3
Publications 3▿
- J Med Chem 60: 7677-7702 (2017) 67
- J Med Chem 60: 7658-7676 (2017) 36
- Bioorg Med Chem 23: 7138-49 (2015) 8
Institutions 1▿
- Takeda Pharmaceutical 111
Affinity: 0.080 to 1.0E+5 nM▿
- IC50 111
- Affinity ≤ nM
Xtal structures: 7
Docked structures: 0
Catalog Cmpds: 4