TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Inhibition of recombinant MK2 (45 to 400 residues) (unknown origin) using fluorescein isothiocyanate-KKKALSRQLSVAA as substrateMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: 96nMAssay Description:Competitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: 310nMAssay Description:Uncompetitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: 320nMAssay Description:Mixed inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: 330nMAssay Description:Inhibition of MK2 in human TERT immortalised HCA2 cells assessed as inhibition of anisomycin-induced HSP27 phosphorylation at 2.5 uM by ELISAMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: 480nMAssay Description:Noncompetitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Competitive inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of MK2 using TAMRA-labeled peptide as substrate pre-incubated for 30 mins prior substrate addition measured after 30 mins incubation in da...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: <3nMAssay Description:Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: <3nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: <3nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: <3nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of MK2 using TAMRA-labeled peptide as substrate pre-incubated for 30 mins prior substrate addition measured after 30 mins incubation in da...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Binding affinity to recombinant MAPKAP-K2 using KKKALSRQLSVAA as substrate after 4 mins by surface plasmon resonance spectroscopic analysisMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human MK2 using hsp27 peptide biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 5.70nMAssay Description:Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 5.70nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 5.70nMAssay Description:Inhibition of MK2 (unknown origin) incubated for 30 mins by MK2 IMAP assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human MAPKAPK2More data for this Ligand-Target Pair
Affinity DataIC50: 6.31nMAssay Description:This study evaluates the inhibitory potency of invention compound on p38/MK2 pathway vs p38/PRAK pathway. More specially the compound concentration (...More data for this Ligand-Target Pair