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Found 12 of ic50 for monomerid = 18678
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]R1881 from wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 after 15 mins by scintillation ass...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  248nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...More data for this Ligand-Target Pair
TargetAndrogen receptor [633-919](Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  248nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  248nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  248nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  264nMAssay Description:Reagents and instruments: radiolabeled dihydrotestosterone (DHT-d3) and unlabelled dihydrotestosterone (DHT) purchased from Sigma-Aldrich (St. Louis,...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  270nMAssay Description:Antagonist activity at wild type human recombinant androgen receptor assessed as inhibition of testosterone-induced growth of mouse androgen dependen...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  350nMAssay Description:Anti-androgenic activity at androgen receptor (unknown origin) expressed in HEK293 cells by BRET assayMore data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
School Of Pharmacy And Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  490nMAssay Description:Antagonist activity at rat androgen receptor fused with DNA-binding domain of GAL4 expressed in AR-UAS-bla GripTite 293 cells assessed as inhibition ...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  490nMAssay Description:Antagonist activity at GAL4 DBD-fused androgen receptor LBD (unknown origin) transfected in UAS-bla GripTite 293 cells assessed as inhibition of R188...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  2.46E+4nMAssay Description:Antagonist activity at androgen receptor (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole-cell voltage-clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed