TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of COX2 in LPS-stimulated human monocytes assessed as reduction in PGE2 production by LC-tandem MIS analysisMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of COX2 in LPS-stimulated human monocytes assessed as reduction in PGE2 production by LC-tandem MIS analysisMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 740nMAssay Description:Inhibition of COX1 in A23187-stimulated human platelets assessed as reduction in TXA2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 740nMAssay Description:Inhibition of COX1 in A23187-stimulated human platelets assessed as reduction in TXA2 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibition of phosphatase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibition of phosphatase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 2(Homo sapiens (Human))
Goethe University Frankfurt
Curated by ChEMBL
Goethe University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inverse agonist activity at Gal4-fused Nurr1 (unknown origin)More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 6.25E+4nMAssay Description:Inhibition of phosphatase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluorescen...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 6.25E+4nMAssay Description:Inhibition of phosphatase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluorescen...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of phosphatase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before FDP substrate addition by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 1.75E+5nMAssay Description:Inhibition of malate dehydrogenase (MDH)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Compound was tested for the inhibition of ChymotrypsinogenMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluorescen...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Mus musculus (Mouse))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length mouse soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length rat soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluorescen...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of hydrolase activity of full length human soluble epoxide hydrolase pre-incubated for 30 mins before PHOME substrate addition by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+5nMAssay Description:Compound was tested for the inhibition of beta-lactamaseMore data for this Ligand-Target Pair