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Found 7 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 3' and Ligand = 'BDBM468609'
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  68.8nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  69nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  1.31E+3nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed