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Found 3 Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor 1-alpha' and Ligand = 'BDBM50315537'
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  40nMAssay Description:Inhibition of HIF-1alpha-mediated VEGF expression in human Hep3b cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  100nMAssay Description:Inhibition of HIF-1alpha-mediated VEGF secretion in human Hep3b cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of HIF-1alpha transcriptional co-activator p300 interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed