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Found 2 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM412676'
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of TYK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM412676(US10399979, Compound 17c)
Affinity DataIC50:  2.24nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent