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Found 15 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2' and Ligand = 'BDBM50020712'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of hERG expressed in HEK293 cells by automated patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human ERG at -90 mV holding potentialMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  3.28E+3nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  3.29E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of [3H]-dofetilide binding to human ERG expressed in HEK293 cell membranes measured after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of [3H]-dofetilide binding to human ERG expressed in HEK293 cell membranes measured after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  1.00E+4nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed