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Found 9 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PLK4' and Ligand = 'BDBM50073587'
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataKi:  0.260nMAssay Description:Competitive inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataKi:  0.260nMAssay Description:Competitive binding to PLK4 (unknown origin) by double reciprocal plot analysis in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50:  0.496nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PLK4 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of PLK4 (unknown origin) by Lanthascreen Eu Kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50: <100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataEC50:  12nMAssay Description:Inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataEC50:  12nMAssay Description:Inhibition of PLK4 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed