Affinity DataIC50: 3.90nMAssay Description:Compound was tested for the binding affinity against sigma receptor by using [3H]-+3PPP as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex after 120 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [3H]ifenprodil from NMDA NR2B receptor in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Compound was tested for the binding affinity against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:In vitro binding affinity against Alpha-1 adrenergic receptor using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Tested for the Alpha-1 adrenergic receptor affinity in a standard radioligand binding assay with [3H]- prazosinMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University Of Strasburg
Curated by ChEMBL
University Of Strasburg
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of NR1/NR2B receptor expressed in xenopus oocytes assessed as effect on L-glutamate and glycine-induced current responseMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Compound was tested for the binding affinity against Alpha-1 adrenergic receptor by using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 135nMAssay Description:Binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human GluN2B expressed in Xenopus laevis oocytes assessed as reduction in glutamate and glycine stimulated ion flux by two-ele...More data for this Ligand-Target Pair
Affinity DataIC50: 238nMAssay Description:Compound was tested for the binding affinity against 5-hydroxytryptamine 1A receptor by using [3H]-DPAT as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 263nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Compound was tested for the binding affinity against 5-hydroxytryptamine 2 receptor by using [3H]-ketanserin as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Compound was tested for the binding affinity against opioid receptor mu by using [3H]naloxone as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Compound was tested for the binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was tested for the binding affinity against histamine H1 receptor by using [3H]-mepyramine as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Compound was tested for the binding affinity against muscarinic acetylcholine receptor
by using [3H]QNB as radioligandMore data for this Ligand-Target Pair
by using [3H]QNB as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Compound was tested for the binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:In vitro inhibitory concentration against NMDA responses at cloned NR1A/2A receptors expressed in Xenopus oocytes More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory concentration against NMDA responses at NR1A/2C receptors expressed in Xenopus oocytesMore data for this Ligand-Target Pair