Found 54 of ic50 for monomerid = 50161957 
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preinc...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human EGFR in presence of 1 mM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.390nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of wild type human N-terminal GST tagged EGFR (669 to 1210 residues) expressed in Sf21 insect cells incubated for 30 mins in presence of A...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R/T790M mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK ...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Homo sapiens (Human))
Temple University Of The Commonwealth System Of Higher Education
US Patent
Temple University Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 1.40nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.73nMAssay Description:EGFR: The compounds' inhibition of target modulation were determined as follows: NCI-H838 cells were sorted in 96 well plates (20000 cells/well) ...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HER2 R896C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATP by P81 ion exchange cellulose chromatographyMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-769,'ASV',770-1210](Homo sapiens (Human))
Temple University Of The Commonwealth System Of Higher Education
US Patent
Temple University Of The Commonwealth System Of Higher Education
US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 1.96nMAssay Description:HER2: The compounds' inhibition of target modulation were determined as follows: BT474 cells were sorted in 96 well plates (20000 cells/well) wit...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant EGFR (unknown origin) after 10 mins by DELFIA/time-resolved fluorometryMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Temple University Of The Commonwealth System Of Higher Education
US Patent
Temple University Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human wild type EGFR expressed in Sf9 cells using [gamma32P]-ATP after 10 mins by scintillation countingMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HER2 V777L mutant (unknown origin) incubated for 120 mins in presence of 33P-ATP by P81 ion exchange cellulose chromatographyMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of wild type human GST-tagged HER2 (676 to end residues) expressed in baculovirus infected Sf9 cells incubated for 30 mins in presence of ...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of HER2 D769H mutant (unknown origin) incubated for 120 mins in presence of 33P-ATP by P81 ion exchange cellulose chromatographyMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:Inhibition of C-terminal His6-tagged HER2 (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated fo...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 13.2nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phosphorylated an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-773,'NPH',774-1210](Homo sapiens (Human))
Temple University Of The Commonwealth System Of Higher Education
US Patent
Temple University Of The Commonwealth System Of Higher Education
US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 13.2nMAssay Description:Table B3: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phospho...More data for this Ligand-Target Pair
Affinity DataIC50: <14nMAssay Description:Inhibiton of EGFR L858R/T790M mutant (unknown origin) expressed in human NCI-H1975 cells assessed as reduction in EGFR induced cell viability after 9...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of HER2 D769Y mutant (unknown origin) incubated for 120 mins in presence of 33P-ATP by P81 ion exchange cellulose chromatographyMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of human Her2More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Irreversible inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Effective concentration against retinoic acid receptor alpha in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (4.6-8.9)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylationMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of HER2 phosphorylation (676 to 1255 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 15 mins i...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of HER2 (unknown origin) in presence of substrate incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of EGFR by cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Irreversible inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of EGFR phosphorylation (645 to 1186 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 15 mins i...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of [3H]-diprenorphine binding to kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of human epidermal growth factor receptor (EGFR) autophosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant wild type EGFR-TK (unknown origin) by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 274nMAssay Description:Inhibition of Nek2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 858nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human VEGFR2 in presence of 1 mM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibiton of EGFR (unknown origin) expressed in human A431 cells assessed as reduction in EGFR induced cell viability after 96 hrs by CellTiter-Glo a...More data for this Ligand-Target Pair
