Compile Data Set for Download or QSAR
maximum 50k data
Found 13 of ic50 for monomerid = 50400902
Target5-hydroxytryptamine receptor 3A(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  0.180nMAssay Description:Binding affinity to rat 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of [3H]serotonin reuptake in rat brain synaptosomes SERT after 15 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Shanghai Institute Of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  5.40nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in xenopus oocytes assessed as inhibition of 5HT-induced effect by electrophysiological methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  890nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human recombinant CYP2D6 using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy- 4-methylcoumarin after 45 mins by fluorescence spectro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4 using resorufin benzyl ether after 30 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of human recombinant CYP2C9 using dibenzylfluorescein after 45 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2 using 7-ethoxy-3-cyanocoumarin after 28 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed