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Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 50003093
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466852(CHEMBL4294976)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human full-length N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in baculovirus expression system using MBP as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha 3(Homo sapiens)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466849(CHEMBL4284240)
Affinity DataIC50:  4nMAssay Description:Inhibition of human full-length N-terminal GST-tagged DYRK1A (1 to 763 residues) expressed in baculovirus expression system using MBP as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466855(CHEMBL4285678)
Affinity DataIC50:  4nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466860(CHEMBL4282315)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human full-length GST-tagged DYRK1A expressed in baculovirus expression system using RRRFRPASPLRGPPK as substrate after 60 mins by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466850(CHEMBL4288045)
Affinity DataIC50:  5nMAssay Description:Inhibition of human full-length GST-tagged DYRK1A expressed in baculovirus expression system using RRRFRPASPLRGPPK as substrate after 60 mins by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466841(CHEMBL4284572)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human full-length GST-tagged DYRK1A expressed in baculovirus expression system using RRRFRPASPLRGPPK as substrate after 60 mins by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466863(CHEMBL4286467)
Affinity DataIC50:  6nMAssay Description:Inhibition of human full-length GST-tagged DYRK1A expressed in baculovirus expression system using RRRFRPASPLRGPPK as substrate after 60 mins by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of recombinant human DYRK1B by radiometric filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of recombinant human DYRK1A by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466848(CHEMBL4283751)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged DYRK1A expressed in baculovirus expression system using DYRKtide-F as substrate aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466852(CHEMBL4294976)
Affinity DataIC50:  8nMAssay Description:Inhibition of human full-length N-terminal GST-tagged DYRK1B (1 to 629 residues) expressed in baculovirus expression system using MBP as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  9nMAssay Description:Inhibition of CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466852(CHEMBL4294976)
Affinity DataIC50:  10nMAssay Description:Inhibition of human full-length N-terminal GST-fused CDK9 (1 to 372 residues) expressed in baculovirus expression system using MBP as substrate after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466860(CHEMBL4282315)
Affinity DataIC50:  14nMAssay Description:Inhibition of human full-length recombinant GST-tagged DYRK1B expressed in baculovirus expression system using RRRFRPASPLRGPPK as substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466849(CHEMBL4284240)
Affinity DataIC50:  15nMAssay Description:Inhibition of full-length human N-terminal GST-fused CLK1 (129 to 484 residues) expressed in baculovirus expression system using MBP as substrate aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466841(CHEMBL4284572)
Affinity DataIC50:  18nMAssay Description:Inhibition of human full-length recombinant GST-tagged DYRK1B expressed in baculovirus expression system using RRRFRPASPLRGPPK as substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  19nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466858(CHEMBL4292553)
Affinity DataIC50:  21nMAssay Description:Inhibition of rat recombinant 6His-tagged DYRK1A (1 to 502 residues) catalytic domain expressed in Escherichia coli BL21 (DE3) using KISGRLSPIMTEQ as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466848(CHEMBL4283751)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged DYRK1B expressed in baculovirus expression system using DYRKtide-F as substrate aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466859(CHEMBL4279616)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant GST-fused CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate in presence of [gamma-33P]ATP after 30 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466847(CHEMBL4283765)
Affinity DataIC50:  32nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  48nMAssay Description:Inhibition of DYRK1A in human HeLa cells assessed as decrease in SF3B1 phosphorylation at Thr434 after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50435473(CHEMBL1236620)
Affinity DataIC50:  55nMAssay Description:Inhibition of DYRK1A (unknown origin) using YRASPSRPESPRPPA-amide as substrate preincubated for 10 mins followed by substrate addition and measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466861(CHEMBL4277878)
Affinity DataIC50:  59nMAssay Description:Inhibition of human full-length GST-tagged DYRK1A expressed in baculovirus expression system using RRRFRPASPLRGPPK as substrate after 60 mins by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human full length DYRK1A using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466845(CHEMBL4291029)
Affinity DataIC50:  81nMAssay Description:Inhibition of GST-tagged DYRK1A (unknown origin) expressed in Escherichia coli DH5alpha using RRRFRPASPLRGPPK as substrate after 30 mins by kinase-gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50047009(1-Methyl-9H-beta-carbolin-7-ol | 1-Methyl-9H-beta-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system assessed as decrease in tau phosphorylation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466859(CHEMBL4279616)
Affinity DataIC50:  91nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli in presence of [gamma-33P]ATP after 30 mins by scintillation counting an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466854(CHEMBL4291088)
Affinity DataIC50:  100nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466857(CHEMBL4288096)
Affinity DataIC50:  110nMAssay Description:Inhibition of DYRK1A Y319E mutant (unknown origin) expressed in HEK293 cells assessed as decrease in tau phosphorylation at Ser97 after 24 hrs by Wes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466843(CHEMBL4283240)
Affinity DataIC50:  181nMAssay Description:Inhibition of GST-tagged DYRK1A (unknown origin) expressed in Escherichia coli DH5alpha using RRRFRPASPLRGPPK as substrate after 30 mins by kinase-gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50445253(CHEMBL1232500)
Affinity DataIC50:  240nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system after 10 mins in presence of [gamma33P-ATP] ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  300nMAssay Description:Inhibition of DYRK1A (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  330nMAssay Description:Inhibition of human recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 40 mins in presence of [gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha/beta(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466862(CHEMBL270722)
Affinity DataIC50:  370nMAssay Description:Inhibition of rat liver CK2 using RRRADDSDDDDD as substrate after 10 mins in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466853(CHEBI:66003 | CHEMBL109269)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system assessed as decrease in tau phosphorylation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50156670(2-(dimethylamino)-4,5,6,7-tetrabromo-1H-benzimidaz...)
Affinity DataIC50:  400nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466847(CHEMBL4283765)
Affinity DataIC50:  410nMAssay Description:Inhibition of GSK-3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466854(CHEMBL4291088)
Affinity DataIC50:  490nMAssay Description:Inhibition of DYRK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466851(CHEMBL4285776)
Affinity DataIC50:  600nMAssay Description:Inhibition of human GST-fused DYRK1A expressed in Escherichia coli BL21 (DE3) using DYRKtide as substrate after 10 mins in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466844(CHEMBL4290278)
Affinity DataIC50:  610nMAssay Description:Inhibition of rat DYRK1A using KKISGRLSPIMTEQ as substrate in presence of [gamma-33P]ATP after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466856(CHEMBL4293650)
Affinity DataIC50:  620nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system assessed as decrease in tau phosphorylation ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human full length DYRK3 using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  900nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human full length DYRK2 using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466842(CHEMBL1615221)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 40 mins in presence of [gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50466854(CHEMBL4291088)
Affinity DataIC50:  910nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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