Compile Data Set for Download or QSAR
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Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50008979
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50218973(CHEMBL44001)
Affinity DataIC50:  8.32nMAssay Description:Inhibition of mouse COX-2 in LPS-induced mouse peritoneal macrophage assessed as reduction in PGE2 release incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Apis mellifera)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524139(CHEMBL4467602)
Affinity DataIC50:  10nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Apis mellifera)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524135(CHEMBL4570349)
Affinity DataIC50:  20nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Apis mellifera)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524140(CHEMBL4447483)
Affinity DataIC50:  30nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50143486(CHEMBL366422 | N-Acetyl-4-[4-(4-methanesulfonyl-ph...)
Affinity DataIC50:  50nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGF2alpha production incubated for 15 mins by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50218964(CHEMBL44223)
Affinity DataIC50:  132nMAssay Description:Inhibition of mouse COX-2 in LPS-induced mouse peritoneal macrophage assessed as reduction in PGE2 release incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50127653(1-(4-Methanesulfonyl-phenyl)-4,5-dihydro-3aH-napht...)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50127652(1-(4-Methanesulfonyl-phenyl)-8-methyl-4,5-dihydro-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Cavia porcellus)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50078688(3-(3,4-Difluoro-phenyl)-4-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  600nMAssay Description:Inhibition of COX2 in guinea pig blood assessed as reduction of LPS-induced PGE2 accumulation at 10 to 10000 nM preincubated with LPS followed by com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Apis mellifera)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524136(CHEMBL4553594)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50125626(5-Hydroxy-4-(4-methanesulfonyl-phenyl)-5-methyl-3-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in PGE2 formation preincubated for 15 mins followed by addition of LPS and measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50219502(4-hydroxyphenyl beta-D-glucopyranoside | Arbutin |...)
Affinity DataIC50: >1.60E+3nMAssay Description:Inhibition of tyrosinase (unknown origin) assessed as reduction in melanin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50125624(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methanesulfonyl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in PGE2 formation preincubated for 15 mins followed by addition of LPS and measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Oryctolagus cuniculus)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50078688(3-(3,4-Difluoro-phenyl)-4-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of COX2 in rabbit whole blood assessed as reduction of LPS-induced PGE2 accumulation at 10 to 10000 nM preincubated with LPS followed by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Apis mellifera)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524137(CHEMBL4452147)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of bee venom phospholipase A2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of GSK3alpha/beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50487746(CHEMBL2262593)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CDK1/cyclinB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human COX2 expressed in CHO cells cells assessed as reduction in PGE2 releaseMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human COX2 expressed in human osteosarcoma cells assessed as reduction in PGE2 releaseMore data for this Ligand-Target Pair
TargetTyrosinase(Homo sapiens (Human))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524138(CHEBI:74456 | CHEMBL3182150)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of tyrosinase (unknown origin) assessed as reduction in melanin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed