Compile Data Set for Download or QSAR
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Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50010555
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length GST-tagged human CDK2/Cyclin AMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant GST-tagged human CDK1/cyclin B expressed in SF-9 cells after 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/cyclin E expressed in SF-9 cells after 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length GST-tagged human CDK1/cyclin BMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540078(CHEMBL4639890)
Affinity DataIC50:  12nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50400802(CHEMBL1235529)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM27217((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human CDK2/cyclin E after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM27217((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human CDK2/cyclin A after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50400802(CHEMBL1235529)
Affinity DataIC50:  40nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM27217((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...)
Affinity DataIC50:  43nMAssay Description:Inhibition of recombinant human CDK9/cyclin T after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  45nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50:  69nMAssay Description:Inhibition of CDK13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM27217((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human CDK5/p25 after 30 mins in presence of [gamma-33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 19(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540078(CHEMBL4639890)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50466842(CHEMBL1615221)
Affinity DataIC50:  110nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  130nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50400802(CHEMBL1235529)
Affinity DataIC50:  140nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  150nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50:  158nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  250nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540077(CHEMBL4649135)
Affinity DataIC50:  321nMAssay Description:Inhibition of CDK2 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50: >500nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50: >500nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  650nMAssay Description:Inhibition of GSK3alpha/beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540077(CHEMBL4649135)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of CDK9 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50235342(CHEMBL319467 | NU-6102)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50330267(4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(...)
Affinity DataIC50:  6.33E+3nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540080(CHEMBL4648857)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540077(CHEMBL4649135)
Affinity DataIC50: >2.80E+4nMAssay Description:Inhibition of CDK1 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540077(CHEMBL4649135)
Affinity DataIC50: >2.80E+4nMAssay Description:Inhibition of CDK7 (unknown origin) in presence of high ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM148264(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM148264(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM60927(1-anilinonaphthalene-8-sulfonic acid | 8-Anilino-1...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM60927(1-anilinonaphthalene-8-sulfonic acid | 8-Anilino-1...)
Affinity DataKd:  3.70E+4nMAssay Description:Binding affinity to CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM154576(K03861 (1))
Affinity DataKd:  53nMAssay Description:Binding affinity to CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540079(CHEMBL4632717)
Affinity DataKd:  5.40nMAssay Description:Binding affinity to CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540079(CHEMBL4632717)
Affinity DataKd:  0.310nMAssay Description:Binding affinity to CDK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50540076(CHEMBL4649097)
Affinity DataKd:  10nMAssay Description:Binding affinity to CDK8/cyclin C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB