Compile Data Set for Download or QSAR
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Report error Found 51 Enz. Inhib. hit(s) with all data for entry = 50012092
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human p56 Lyn tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human Tyrosine-protein kinase CSKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  42nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114591(5-(4-Phenoxy-phenyl)-7-(tetrahydro-furan-3-yl)-7H-...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114582(7-Isoxazolidin-4-yl-5-(4-phenoxy-phenyl)-7H-pyrrol...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human B lymphoid tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human p55 Fyn tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114583(5-(4-Phenoxy-phenyl)-7-(4-piperidin-1-yl-cyclohexy...)
Affinity DataIC50:  82nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50092228(4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114590(5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114586(2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114587(5-(4-Phenoxy-phenyl)-7-piperidin-4-yl-7H-pyrrolo[2...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114588(5-(4-Phenoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  250nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114583(5-(4-Phenoxy-phenyl)-7-(4-piperidin-1-yl-cyclohexy...)
Affinity DataIC50:  298nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114591(5-(4-Phenoxy-phenyl)-7-(tetrahydro-furan-3-yl)-7H-...)
Affinity DataIC50:  320nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  370nMAssay Description:Inhibition of human B lymphoid tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114582(7-Isoxazolidin-4-yl-5-(4-phenoxy-phenyl)-7H-pyrrol...)
Affinity DataIC50:  390nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human p56 Lyn tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114589(5-(4-Phenoxy-phenyl)-7-(4-piperidin-1-yl-cyclohexy...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50092228(4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  560nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114584(7-(2-Amino-ethyl)-5-(4-phenoxy-phenyl)-7H-pyrrolo[...)
Affinity DataIC50:  890nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114590(5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114586(2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114587(5-(4-Phenoxy-phenyl)-7-piperidin-4-yl-7H-pyrrolo[2...)
Affinity DataIC50:  1.78E+3nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  2.03E+3nMAssay Description:Inhibition of human p55 Fyn tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114588(5-(4-Phenoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[...)
Affinity DataIC50:  2.36E+3nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  4.27E+3nMAssay Description:Inhibition of human Csk tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50092228(4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  4.44E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114591(5-(4-Phenoxy-phenyl)-7-(tetrahydro-furan-3-yl)-7H-...)
Affinity DataIC50:  5.15E+3nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114589(5-(4-Phenoxy-phenyl)-7-(4-piperidin-1-yl-cyclohexy...)
Affinity DataIC50:  5.46E+3nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  5.85E+3nMAssay Description:Inhibition of TIE-2 kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114582(7-Isoxazolidin-4-yl-5-(4-phenoxy-phenyl)-7H-pyrrol...)
Affinity DataIC50:  6.62E+3nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50092228(4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  9.07E+3nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114590(5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114589(5-(4-Phenoxy-phenyl)-7-(4-piperidin-1-yl-cyclohexy...)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114586(2-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyri...)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of cMet kinase (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Cell division control protein 2, Cdk-1 (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70kDa, Zap70 (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of insulin receptor kinase (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114587(5-(4-Phenoxy-phenyl)-7-piperidin-4-yl-7H-pyrrolo[2...)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114584(7-(2-Amino-ethyl)-5-(4-phenoxy-phenyl)-7H-pyrrolo[...)
Affinity DataIC50:  3.23E+4nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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