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Found 41 Enz. Inhib. hit(s) with all data for entry = 50015404
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586310(CHEMBL5093029)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586307(CHEMBL5087826)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of ERK1 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586299(CHEMBL5076561)
Affinity DataIC50:  3nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586306(CHEMBL5089637)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586300(CHEMBL5082830)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586296(CHEMBL5092545)
Affinity DataIC50:  6nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586301(CHEMBL5073083)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586292(CHEMBL5086221)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586305(CHEMBL5081036)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586294(CHEMBL5085508)
Affinity DataIC50:  14nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  14nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586308(CHEMBL5076006)
Affinity DataIC50:  16nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586311(CHEMBL5090465)
Affinity DataIC50:  18nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586302(CHEMBL5077010)
Affinity DataIC50:  39nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586309(CHEMBL5092813)
Affinity DataIC50:  45nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  64nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586295(CHEMBL5085912)
Affinity DataIC50:  99nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  99nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586298(CHEMBL5094193)
Affinity DataIC50:  130nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586303(CHEMBL5091739)
Affinity DataIC50:  188nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586291(CHEMBL5080686)
Affinity DataIC50:  201nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  224nMAssay Description:Inhibition of ERK1/2 in human COLO 205 cells assessed as inhibition of RSK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586304(CHEMBL5086119)
Affinity DataIC50:  237nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586290(CHEMBL5078454)
Affinity DataIC50:  240nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586299(CHEMBL5076561)
Affinity DataIC50:  350nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  790nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586297(CHEMBL5093914)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586293(CHEMBL5088768)
Affinity DataIC50:  4.83E+3nMAssay Description:Inhibition of ERK2 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586299(CHEMBL5076561)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586299(CHEMBL5076561)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586299(CHEMBL5076561)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586299(CHEMBL5076561)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed