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Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50015965
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50:  49nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  180nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162975(4-(3H-Benzoimidazol-5-ylamino)-6-(1-methyl-1-pheny...)
Affinity DataIC50:  240nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  280nMAssay Description:Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162974(4-(Benzothiazol-5-ylamino)-6-(benzyl-methyl-amino)...)
Affinity DataIC50:  320nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162974(4-(Benzothiazol-5-ylamino)-6-(benzyl-methyl-amino)...)
Affinity DataIC50:  320nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50:  400nMAssay Description:Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50:  420nMAssay Description:Inhibition of beta IRK tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50:  550nMAssay Description:Inhibition of beta IRK tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162977(4-(Benzothiazol-6-yl-methyl-amino)-6-(1-methyl-1-p...)
Affinity DataIC50:  1.60E+3nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162981(4-(Benzothiazol-6-ylamino)-6-benzylamino-[1,3,5]tr...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of PDGF-R2 tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of PDGF-R2 tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of beta IRK tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of c-fms tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162980(CHEMBL175760 | N-Benzothiazol-6-yl-6-chloro-N''-(1...)
Affinity DataIC50:  5.50E+3nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162980(CHEMBL175760 | N-Benzothiazol-6-yl-6-chloro-N''-(1...)
Affinity DataIC50:  5.50E+3nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162979(CHEMBL175506 | N-Benzothiazol-6-yl-6-methoxy-N''-(...)
Affinity DataIC50:  6.10E+3nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of PDGF-R2 tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162977(4-(Benzothiazol-6-yl-methyl-amino)-6-(1-methyl-1-p...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Mus musculus)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Mus musculus)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Insulin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Insulin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Insulin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Mus musculus)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162978(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Mus musculus)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Insulin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of beta IRK tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of PDGF-R2 tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162976(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of c-fms tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162972(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Affinity DataIC50: >1.25E+4nMAssay Description:Inhibition of c-fms tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162973(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of c-fms tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162975(4-(3H-Benzoimidazol-5-ylamino)-6-(1-methyl-1-pheny...)
Affinity DataIC50: >2.00E+4nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162981(4-(Benzothiazol-6-ylamino)-6-benzylamino-[1,3,5]tr...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50162979(CHEMBL175506 | N-Benzothiazol-6-yl-6-methoxy-N''-(...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed