Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 50017353
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50541592(CHEMBL3187788)
Affinity DataKi:  0.400nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50515430(NETARSUDIL | US11608319, Compound AR-13324)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50515430(NETARSUDIL | US11608319, Compound AR-13324)
Affinity DataKi:  1nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601415(AR-12286 | AR-12286 FREE BASE | Ar-12286 | VEROSUD...)
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601415(AR-12286 | AR-12286 FREE BASE | Ar-12286 | VEROSUD...)
Affinity DataKi:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601416(CHEMBL5182402)
Affinity DataKi:  5nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601416(CHEMBL5182402)
Affinity DataKi:  14nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataKi:  28nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50417857(CHEMBL1667969)
Affinity DataKi:  36nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  140nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  300nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataKi:  330nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEphrin type-A receptor 4(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM223311(123C4)
Affinity DataKi:  640nMAssay Description:Competitive binding affinity to EphA4 ligand binding domain (unknown origin) using FITC-labelled EphA4 (KYLPYWPVLSSL) as a substrate assessed as inhi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of recombinant human full length P13Kdelta expressed in Sf9 cells assessed as reduction in ATP-dependent phosphorylation by chromatography...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM188514(4,7,7-trimethyl-4-phenyl-3-(trifluoromethyl)-2,4,6...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of GSK3alpha (unknown origin) by ADP-glo analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124208(ASP-015K | ASP015K | Peficitinib)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601417(CHEMBL5178166)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50557487(Tolebrutinib)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50040805(CHEMBL3361255)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601417(CHEMBL5178166)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50:  2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50374681(CHEMBL257834)
Affinity DataIC50:  2nMAssay Description:Inhibition of human MK2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124208(ASP-015K | ASP015K | Peficitinib)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50269948(6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant FAK (410 to 689 residues) (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124208(ASP-015K | ASP015K | Peficitinib)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124208(ASP-015K | ASP015K | Peficitinib)
Affinity DataIC50:  5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-adrenergic receptor kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of GRK3 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  5.70nMAssay Description:Reversible inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  5.90nMAssay Description:Reversible inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50505940(CHEMBL4449840)
Affinity DataIC50:  6nMAssay Description:Inhibition of ASK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50040806(CHEMBL3361254)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601414(CHEMBL5173945)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant GSK3betaMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50386749(CHEMBL2046883)
Affinity DataIC50:  10nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601414(CHEMBL5173945)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant GSK3alphaMore data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM27344(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDC7 (unknown origin)More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50:  10nMAssay Description:Inhibition of KHK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM402040(Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-met...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50443871(CHEMBL3091536)
Affinity DataIC50:  12nMAssay Description:Inhibition of human GSK3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50:  15nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  17nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50087135(CHEMBL3426621)
Affinity DataIC50:  19nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50:  20nMAssay Description:Inhibition of GRK2 (unknown origin) in presence of ATP at 5 uMMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  25nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Displayed 1 to 50 (of 81 total ) | Next | Last >>
Jump to: