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Report error Found 219 Enz. Inhib. hit(s) with all data for entry = 50037621
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50412114(CHEMBL183460 | SB-649915)
Affinity DataKi:  0.320nMAssay Description:Negative logarithm causing 50% receptor occupancy against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50150105(CHEMBL124069 | [2-(6-Fluoro-chroman-8-yloxy)-ethyl...)
Affinity DataKi:  0.5nMAssay Description:Inhibition constant against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50027185(CHEMBL183921)
Affinity DataKi:  0.630nMAssay Description:Negative logarithm causing 50% receptor occupancy against beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50027185(CHEMBL183921)
Affinity DataKi:  0.790nMAssay Description:Negative logarithm causing 50% receptor occupancy against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory concentration against angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175523(4''-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory concentration against angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50109061(3-{1-[2-(1H-Indol-4-yloxy)-ethyl]-1,2,3,6-tetrahyd...)
Affinity DataKi:  1nMAssay Description:Inhibition constant against alpha adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50115848((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((S)-5-m...)
Affinity DataKi:  1.30nMAssay Description:Inhibition constant against angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50109061(3-{1-[2-(1H-Indol-4-yloxy)-ethyl]-1,2,3,6-tetrahyd...)
Affinity DataKi:  1.5nMAssay Description:Inhibition constant against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50027184(CHEMBL180700)
Affinity DataKi:  1.60nMAssay Description:Negative logarithm causing 50% receptor occupancy against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50117910(4''-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-...)
Affinity DataKi:  1.90nMAssay Description:Inhibitory concentration against endothelin receptor type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50057128((2-Benzofuran-6-yl-ethyl)-((R)-5-methoxy-1,2,3,4-t...)
Affinity DataKi:  2nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175525(CHEMBL198045 | [2-(3-Fluoro-phenyl)-ethyl]-(5-meth...)
Affinity DataKi:  3.20nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  4.60nMAssay Description:Inhibition constant against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  4.70nMAssay Description:Inhibition constant against dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  5.30nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50412114(CHEMBL183460 | SB-649915)
Affinity DataKi:  6.30nMAssay Description:Negative logarithm causing 50% receptor occupancy against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50057093((2-Benzo[1,3]dioxol-5-yl-ethyl)-(5-methoxy-1,2,3,4...)
Affinity DataKi:  6.70nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  6.90nMAssay Description:Inhibition constant against nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50128875(CHEMBL292195 | [3-(4-Chloro-phenyl)-3-pyridin-2-yl...)
Affinity DataKi:  7nMAssay Description:Inhibition constant against histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50082412(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)
Affinity DataKi:  8.30nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175523(4''-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-...)
Affinity DataKi:  9.30nMAssay Description:Inhibitory concentration against endothelin receptor type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50115848((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((S)-5-m...)
Affinity DataKi:  10nMAssay Description:Inhibition constant against endothelin converting enzyme 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175502(CHEMBL383581 | N-[2'-(4,5-Dimethyl-isoxazol-3-ylsu...)
Affinity DataKi:  10nMAssay Description:Inhibitory concentration against endothelin receptor type AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175502(CHEMBL383581 | N-[2'-(4,5-Dimethyl-isoxazol-3-ylsu...)
Affinity DataKi: >10nMAssay Description:Inhibitory concentration against angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50117910(4''-(2-Butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-...)
Affinity DataKi:  10nMAssay Description:Inhibitory concentration against angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50082412(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)
Affinity DataKi:  10nMAssay Description:Inhibition constant against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50002088(CHEMBL302005 | [11-(2-Dimethylamino-ethylidene)-6,...)
Affinity DataKi:  11nMAssay Description:Inhibition constant against histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50109061(3-{1-[2-(1H-Indol-4-yloxy)-ethyl]-1,2,3,6-tetrahyd...)
Affinity DataKi:  11nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM22890(2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-...)
Affinity DataKi:  14nMAssay Description:Inhibition constant against histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50128875(CHEMBL292195 | [3-(4-Chloro-phenyl)-3-pyridin-2-yl...)
Affinity DataKi:  15nMAssay Description:Inhibition constant against histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175524(11-[2-Benzoimidazol-1-yl-eth-(E)-ylidene]-6,11-dih...)
Affinity DataKi:  15nMAssay Description:Inhibition constant against thromboxane A2 receptor to prostaglandin H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  16nMAssay Description:Inhibition constant against alpha adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  16nMAssay Description:Inhibition constant against norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175516(CHEMBL372588 | {11-[2-(4-Benzyl-piperidin-1-yl)-et...)
Affinity DataKi:  20nMAssay Description:Inhibition constant against histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50027183(CHEMBL326134)
Affinity DataKi:  24nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50115848((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((S)-5-m...)
Affinity DataKi:  24nMAssay Description:Inhibitory concentration against neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50403993(CHEMBL91418)
Affinity DataKi:  25nMAssay Description:Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50150105(CHEMBL124069 | [2-(6-Fluoro-chroman-8-yloxy)-ethyl...)
Affinity DataKi:  27nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50403993(CHEMBL91418)
Affinity DataKi:  32nMAssay Description:Negative logarithm causing 50% receptor occupancy against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175510(CHEMBL196071 | N-(4-Guanidino-butyl)-N-(1-phenethy...)
Affinity DataKi:  33nMAssay Description:Binding affinity towards opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50138436(CHEMBL146997 | N-(8-Guanidino-octyl)-N-(1-phenethy...)
Affinity DataKi:  37nMAssay Description:Binding affinity towards imidazoline receptor I-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175514(1N,1N-diethyl-2-[2-hydroxy-3-(1H-4-indolyloxy)prop...)
Affinity DataKi:  45nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175501(3-Chloro-7-{2-[(R)-4-(6-fluoro-naphthalen-1-yl)-2-...)
Affinity DataKi:  45nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataKi:  48nMAssay Description:Inhibition constant against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50027185(CHEMBL183921)
Affinity DataKi:  50nMAssay Description:Negative logarithm causing 50% receptor occupancy against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50057128((2-Benzofuran-6-yl-ethyl)-((R)-5-methoxy-1,2,3,4-t...)
Affinity DataKi:  52nMAssay Description:Inhibition constant against Dopamine receptor D2 in olfactory bulbectomized ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataKi:  56nMAssay Description:Inhibition constant against 5-HT 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50027184(CHEMBL180700)
Affinity DataKi:  79nMAssay Description:Negative logarithm causing 50% receptor occupancy against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)
Affinity DataKi:  110nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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