Compile Data Set for Download or QSAR
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Report error Found 59 Enz. Inhib. hit(s) with all data for entry = 50047821
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191472(CHEMBL3956719)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191414(CHEMBL3947140)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191472(CHEMBL3956719)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191373(CHEMBL3966985)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191373(CHEMBL3966985)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191414(CHEMBL3947140)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191371(CHEMBL3939280)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191443(CHEMBL3938208)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191467(CHEMBL3911320)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191469(CHEMBL3895703)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727More data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191358(CHEMBL3938357)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191361(CHEMBL3948055)
Affinity DataIC50:  9nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50:  9nMAssay Description:Inhibition of CDK8 in human COLO205 cells expressing APC mutant assessed as suppression of WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191353(CHEMBL3916750)
Affinity DataIC50:  11nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191469(CHEMBL3895703)
Affinity DataIC50:  12nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191356(CHEMBL3967915)
Affinity DataIC50:  15nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191354(CHEMBL3934243)
Affinity DataIC50:  17nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191371(CHEMBL3939280)
Affinity DataIC50:  19nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191372(CHEMBL3955876)
Affinity DataIC50:  24nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191467(CHEMBL3911320)
Affinity DataIC50:  28nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191473(CHEMBL3929167)
Affinity DataIC50:  32nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50:  32nMAssay Description:Inhibition of CDK8 in human LS174T cells expressing beta-catenin mutant assessed as suppression of WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191355(CHEMBL3975326)
Affinity DataIC50:  32nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191468(CHEMBL3984494)
Affinity DataIC50:  45nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191360(CHEMBL3964636)
Affinity DataIC50:  49nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50:  52nMAssay Description:Inhibition of CDK8 in human PA1 cells assessed as suppression of WNT3a ligand-induced WNT pathway by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191471(CHEMBL3906261)
Affinity DataIC50:  60nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191443(CHEMBL3938208)
Affinity DataIC50:  70nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191474(CHEMBL3899488)
Affinity DataIC50:  77nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191361(CHEMBL3948055)
Affinity DataIC50:  90nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191467(CHEMBL3911320)
Affinity DataIC50:  90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191354(CHEMBL3934243)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191473(CHEMBL3929167)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191470(CHEMBL3967778)
Affinity DataIC50:  110nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191358(CHEMBL3938357)
Affinity DataIC50:  115nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191355(CHEMBL3975326)
Affinity DataIC50:  120nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191353(CHEMBL3916750)
Affinity DataIC50:  125nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191359(CHEMBL3890533)
Affinity DataIC50:  129nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191372(CHEMBL3955876)
Affinity DataIC50:  150nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191467(CHEMBL3911320)
Affinity DataIC50:  219nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191356(CHEMBL3967915)
Affinity DataIC50:  230nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191467(CHEMBL3911320)
Affinity DataIC50:  279nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191467(CHEMBL3911320)
Affinity DataIC50:  286nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191471(CHEMBL3906261)
Affinity DataIC50:  290nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191474(CHEMBL3899488)
Affinity DataIC50:  415nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191360(CHEMBL3964636)
Affinity DataIC50:  435nMAssay Description:Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50191357(CHEMBL3903492)
Affinity DataIC50:  691nMAssay Description:Inhibition of GSK-3alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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