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Found 138 of ph data with Target = 'Aurora kinase B'
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM236509(US9394281, 8)
Affinity DataIC50:  31nMpH: 7.0 T: 2°CAssay Description:Aurora-B (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 μM AKRRRLSSLRA, 10 mM MgAcetate and [γ-33PATP](specific activity approx. 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM236507(US9394281, 5)
Affinity DataIC50:  50nMpH: 7.0 T: 2°CAssay Description:Aurora-B (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 μM AKRRRLSSLRA, 10 mM MgAcetate and [γ-33PATP](specific activity approx. 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM47238(US9012475, MLN8237)
Affinity DataIC50:  90nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  90nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM50381716(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)
Affinity DataIC50:  7.87nMpH: 7.4Assay Description:To determine Aurora B activity of representative compounds of the invention, Active Aurora B enzyme (recombinant residues 1-344) and INCENP (recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM121388(US8722890, 3)
Affinity DataIC50:  11.2nMpH: 7.4Assay Description:To determine Aurora B activity of representative compounds of the invention, Active Aurora B enzyme (recombinant residues 1-344) and INCENP (recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM121389(US8722890, 4)
Affinity DataIC50:  14.8nMpH: 7.4Assay Description:To determine Aurora B activity of representative compounds of the invention, Active Aurora B enzyme (recombinant residues 1-344) and INCENP (recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM121390(US8722890, 5)
Affinity DataIC50:  28.9nMpH: 7.4Assay Description:To determine Aurora B activity of representative compounds of the invention, Active Aurora B enzyme (recombinant residues 1-344) and INCENP (recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM50381698(CHEMBL1969102 | US8722890, 6)
Affinity DataIC50:  8.44nMpH: 7.4Assay Description:To determine Aurora B activity of representative compounds of the invention, Active Aurora B enzyme (recombinant residues 1-344) and INCENP (recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  110nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibitory activity of the compound against Aurora B kinase activity was assayed with reference to a method described in patent public...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155565(US10092556, Example 1 | US9012475, 1 | US9346787, ...)
Affinity DataIC50:  140nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155566(US10092556, Example 2 | US9012475, 2 | US9346787, ...)
Affinity DataIC50:  340nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155567(US10092556, Example 11 | US9012475, 11 | US9346787...)
Affinity DataIC50:  930nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155568(US10092556, Example 12 | US9012475, 12 | US9346787...)
Affinity DataIC50:  260nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155569(US10092556, Example 13 | US9012475, 13 | US9346787...)
Affinity DataIC50:  180nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155570(US10092556, Example 14 | US9012475, 14 | US9346787...)
Affinity DataIC50:  460nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155571(US10092556, Example 17 | US9012475, 17 | US9346787...)
Affinity DataIC50:  900nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155572(US10092556, Example 19 | US9012475, 19 | US9346787...)
Affinity DataIC50:  880nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155573(US10092556, Example 22 | US9012475, 22 | US9346787...)
Affinity DataIC50:  380nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155574(US10092556, Example 24 | US9012475, 24 | US9346787...)
Affinity DataIC50:  190nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155575(US10092556, Example 28 | US9012475, 28 | US9346787...)
Affinity DataIC50:  450nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155576(US10092556, Example 29 | US9012475, 29 | US9346787...)
Affinity DataIC50:  390nMpH: 7.4Assay Description:The method for measuring the in-vitro inhibitory activity of a test compound against Aurora B kinase activity was substantially the same as in the ca...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM182768(US9145414, 24)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibitory activity of the compound against Aurora B kinase activity was assayed with reference to a method described in patent public...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM182797(US9145414, 160)
Affinity DataIC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibitory activity of the compound against Aurora B kinase activity was assayed with reference to a method described in patent public...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM182798(US9145414, 161)
Affinity DataIC50:  420nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibitory activity of the compound against Aurora B kinase activity was assayed with reference to a method described in patent public...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155565(US10092556, Example 1 | US9012475, 1 | US9346787, ...)
Affinity DataIC50:  140nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155566(US10092556, Example 2 | US9012475, 2 | US9346787, ...)
Affinity DataIC50:  340nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155567(US10092556, Example 11 | US9012475, 11 | US9346787...)
Affinity DataIC50:  930nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155568(US10092556, Example 12 | US9012475, 12 | US9346787...)
Affinity DataIC50:  260nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155569(US10092556, Example 13 | US9012475, 13 | US9346787...)
Affinity DataIC50:  180nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155570(US10092556, Example 14 | US9012475, 14 | US9346787...)
Affinity DataIC50:  460nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155571(US10092556, Example 17 | US9012475, 17 | US9346787...)
Affinity DataIC50:  900nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155572(US10092556, Example 19 | US9012475, 19 | US9346787...)
Affinity DataIC50:  680nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155573(US10092556, Example 22 | US9012475, 22 | US9346787...)
Affinity DataIC50:  380nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155574(US10092556, Example 24 | US9012475, 24 | US9346787...)
Affinity DataIC50:  190nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155575(US10092556, Example 28 | US9012475, 28 | US9346787...)
Affinity DataIC50:  450nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155576(US10092556, Example 29 | US9012475, 29 | US9346787...)
Affinity DataIC50:  390nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM231252(US10092556, Comparative Example 6 | US9346787, Com...)
Affinity DataIC50:  320nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  90nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155565(US10092556, Example 1 | US9012475, 1 | US9346787, ...)
Affinity DataIC50:  140nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155566(US10092556, Example 2 | US9012475, 2 | US9346787, ...)
Affinity DataIC50:  340nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155567(US10092556, Example 11 | US9012475, 11 | US9346787...)
Affinity DataIC50:  930nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155568(US10092556, Example 12 | US9012475, 12 | US9346787...)
Affinity DataIC50:  260nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155569(US10092556, Example 13 | US9012475, 13 | US9346787...)
Affinity DataIC50:  180nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155570(US10092556, Example 14 | US9012475, 14 | US9346787...)
Affinity DataIC50:  460nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155571(US10092556, Example 17 | US9012475, 17 | US9346787...)
Affinity DataIC50:  900nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155572(US10092556, Example 19 | US9012475, 19 | US9346787...)
Affinity DataIC50:  680nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155573(US10092556, Example 22 | US9012475, 22 | US9346787...)
Affinity DataIC50:  380nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155574(US10092556, Example 24 | US9012475, 24 | US9346787...)
Affinity DataIC50:  190nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM155575(US10092556, Example 28 | US9012475, 28 | US9346787...)
Affinity DataIC50:  450nMpH: 7.4Assay Description:The in vitro method for measuring the inhibitory activity of the test compound on the aurora B kinase activity was performed in a similar manner as t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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