Affinity DataIC50: >5.00E+5nMpH: 7.4 T: 2°CAssay Description:The effect of compound on cytochrome P450 (CYP) enzyme catalytic activity was determined in human liver microsomes, using a cocktail of probe substra...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMpH: 7.4Assay Description:Specific aspects of the incubation conditions for each assay (e.g., protein concentration, incubation time, etc.) are defined in Walsky & Obach, 2004...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.4Assay Description:Specific aspects of the incubation conditions for each assay (e.g., protein concentration, incubation time, etc.) are defined in Walsky & Obach, 2004...More data for this Ligand-Target Pair
Affinity DatapH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMpH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+4nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
Affinity DataIC50: 2.24E+4nMpH: 7.4 T: 2°CAssay Description:Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in e...More data for this Ligand-Target Pair
Affinity DataIC50: 7.57E+4nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMpH: 7.4 T: 2°CAssay Description:A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.4Assay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Binding affinity to CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of reconstituted CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of reconstituted CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of reconstituted CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Binding affinity to CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Binding affinity to CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibition of reconstituted CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Binding affinity to CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 44.3nMAssay Description:Binding affinity to CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Inhibition of reconstituted CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Binding affinity was measured on Cytochrome P450 2C9More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Binding affinity measured on human cytochrome P450 2C9 (CYP2C9) enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Binding affinity was measured on Cytochrome P450 2C9More data for this Ligand-Target Pair
Affinity DataKi: 101nMAssay Description:Binding affinity to CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 113nMAssay Description:Inhibition of purified CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 125nMAssay Description:Inhibition of reconstituted CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 152nMAssay Description:Inhibition of reconstituted CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Binding affinity measured on human cytochrome P450 2C9 (CYP2C9) enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 280nMAssay Description:Inhibition of human cytochrome P450 2C9More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Binding affinity was measured on Cytochrome P450 2C9More data for this Ligand-Target Pair