Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 8835
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  26.8nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422046(US10508102, Compound A)
Affinity DataEC50:  256nMAssay Description:RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422046(US10508102, Compound A)
Affinity DataEC50:  90.5nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422046(US10508102, Compound A)
Affinity DataEC50:  324nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  26.8nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  86.6nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422048(US10508102, Compound B)
Affinity DataEC50: >1.00E+5nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422049(US10508102, Compound E)
Affinity DataEC50:  2.33E+3nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422049(US10508102, Compound E)
Affinity DataEC50:  8.33E+3nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422050(US10508102, Compound F)
Affinity DataEC50:  1.05E+4nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422050(US10508102, Compound F)
Affinity DataEC50: >1.00E+5nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422051(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(2-fluoroben...)
Affinity DataEC50:  159nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422051(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(2-fluoroben...)
Affinity DataEC50:  1.10E+4nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422052(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3-fluoroben...)
Affinity DataEC50:  41nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422052(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3-fluoroben...)
Affinity DataEC50:  895nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422053(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3,4-difluor...)
Affinity DataEC50:  89nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422053(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3,4-difluor...)
Affinity DataEC50:  426nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422054(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(4-fluoroben...)
Affinity DataEC50:  220nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422054(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(4-fluoroben...)
Affinity DataEC50:  867nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422055(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2-...)
Affinity DataEC50:  235nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422055(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2-...)
Affinity DataEC50:  892nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422056(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2,...)
Affinity DataEC50:  50nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422056(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2,...)
Affinity DataEC50:  822nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422057(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(3,...)
Affinity DataEC50:  121nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422057(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(3,...)
Affinity DataEC50:  722nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422058(US10508102, Example C1)
Affinity DataEC50:  343nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  93.7nMAssay Description:RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President And Fellows Of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  86.6nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent