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Patent code US10793563

Compile Data Set for Download or QSAR

Found 532 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464703
PNG
(US10793563, Compound I-25)
Show SMILES CS(=O)(=O)NCC1CCN(C1)c1ccnc(n1)-c1cnc2cc(F)c(Br)cn12
Show InChI InChI=1S/C17H18BrFN6O2S/c1-28(26,27)22-7-11-3-5-24(9-11)15-2-4-20-17(23-15)14-8-21-16-6-13(19)12(18)10-25(14)16/h2,4,6,8,10-11,22H,3,5,7,9H2,1H3
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464789
PNG
(US10793563, Compound I-380)
Show SMILES CC1C(NCCN1c1ccnc(n1)-c1cnc2ccc(cn12)C(F)(F)F)C(N)=O
Show InChI InChI=1S/C18H18F3N7O/c1-10-15(16(22)29)23-6-7-27(10)14-4-5-24-17(26-14)12-8-25-13-3-2-11(9-28(12)13)18(19,20)21/h2-5,8-10,15,23H,6-7H2,1H3,(H2,22,29)
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<10n/an/an/an/an/an/an/an/a



MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464717
PNG
(US10793563, Compound I-39 | US10793563, Compound I...)
Show SMILES CC1CN(CC(N1)c1cn[nH]c1)c1nccc(n1)-c1cnc2ccc(cn12)C(F)(F)F
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464771
PNG
(US10793563, Compound I-108)
Show SMILES FC(F)(F)c1ccc2ncc(-c3nc(ns3)N3CCOC(C3)c3cn[nH]c3)n2c1
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<10n/an/an/an/an/an/an/an/a



MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464780
PNG
(US10793563, Compound I-116)
Show SMILES C[C@H]1CN(C[C@H](O1)c1cn[nH]c1C)c1nccc(n1)-c1cnc2ccc(cn12)C(F)(F)F
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<10n/an/an/an/an/an/an/an/a



MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464781
PNG
(US10793563, Compound I-117 | US10793563, Compound ...)
Show SMILES C[C@@H]1CN(C[C@@H](O1)c1cn[nH]c1)c1nccc(n1)-c1cnc2ccc(cn12)C(F)(F)F
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<10n/an/an/an/an/an/an/an/a



MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464783
PNG
(US10793563, Compound I-119)
Show SMILES C[C@@H]1CN(C[C@@H](O1)c1c[nH]nc1C)c1ccnc(n1)-c1cnc2ccc(cn12)C(F)(F)F
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464790
PNG
(US10793563, Compound I-484)
Show SMILES CC1C(N(CCN1c1ccnc(n1)-c1cnc2ccc(Cl)cn12)C1CC1)C(N)=O
Show InChI InChI=1S/C20H22ClN7O/c1-12-18(19(22)29)27(14-3-4-14)9-8-26(12)17-6-7-23-20(25-17)15-10-24-16-5-2-13(21)11-28(15)16/h2,5-7,10-12,14,18H,3-4,8-9H2,1H3,(H2,22,29)
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464707
PNG
(US10793563, Compound I-29)
Show SMILES CP(C)(=O)C1CC(CN(C1)c1ccnc(n1)-c1cnc2ccc(Cl)cn12)c1cn[nH]c1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464714
PNG
(US10793563, Compound I-36)
Show SMILES CC1CN(C(C)C(N1)c1cn[nH]c1)c1ccnc(n1)-c1cnc2ccc(Cl)cn12
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464694
PNG
(US10793563, Compound I-16 | US10793563, Compound I...)
Show SMILES C[C@H]1CN(C[C@@H](CNS(C)(=O)=O)C1(F)F)c1nccc(n1)-c1cnc2ccc(cn12)C(F)F
Show InChI InChI=1S/C20H22F4N6O2S/c1-12-9-29(11-14(20(12,23)24)7-27-33(2,31)32)19-25-6-5-15(28-19)16-8-26-17-4-3-13(18(21)22)10-30(16)17/h3-6,8,10,12,14,18,27H,7,9,11H2,1-2H3/t12-,14+/m0/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464683
PNG
(US10793563, Compound I-43 | US10793563, Compound I...)
Show SMILES FC(F)(F)c1ccc2ncc(-c3nccc(n3)N3CCN4C(CNC4=O)C3)n2c1
Show InChI InChI=1S/C18H16F3N7O/c19-18(20,21)11-1-2-14-23-8-13(28(14)9-11)16-22-4-3-15(25-16)26-5-6-27-12(10-26)7-24-17(27)29/h1-4,8-9,12H,5-7,10H2,(H,24,29)
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464680
PNG
(US10793563, Compound I-2 | US10793563, Compound I-...)
Show SMILES FC(F)(F)c1ccc2ncc(-c3nccc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464730
PNG
(US10793563, Compound I-52 | US10793563, Compound I...)
Show SMILES CC1CC(C(C)N(C1)c1ccnc(n1)-c1cnc2cc(F)c(Cl)cn12)C(N)=O
Show InChI InChI=1S/C19H20ClFN6O/c1-10-5-12(18(22)28)11(2)26(8-10)16-3-4-23-19(25-16)15-7-24-17-6-14(21)13(20)9-27(15)17/h3-4,6-7,9-12H,5,8H2,1-2H3,(H2,22,28)
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464753
PNG
(US10793563, Compound I-90)
Show SMILES C[C@@H]1CN(C[C@@H](O1)c1nc(C)no1)c1ccnc(n1)-c1cnc2ccc(cn12)C(F)(F)F
Show InChI InChI=1S/C20H18F3N7O2/c1-11-8-29(10-15(31-11)19-26-12(2)28-32-19)17-5-6-24-18(27-17)14-7-25-16-4-3-13(9-30(14)16)20(21,22)23/h3-7,9,11,15H,8,10H2,1-2H3/t11-,15-/m1/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464765
PNG
(US10793563, Compound I-102)
Show SMILES NC(=O)[C@H]1CCCN(C1)c1ccnc(n1)-c1cnc2ccc(Cl)cn12
Show InChI InChI=1S/C17H17ClN6O/c18-12-3-4-14-21-8-13(24(14)10-12)17-20-6-5-15(22-17)23-7-1-2-11(9-23)16(19)25/h3-6,8,10-11H,1-2,7,9H2,(H2,19,25)/t11-/m0/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464784
PNG
(US10793563, Compound I-120 | US10793563, Compound ...)
Show SMILES C[C@@H]1CN(C[C@@H](O1)c1cn[nH]c1C)c1ccnc(n1)-c1cnc2ccc(cn12)C(F)(F)F
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464687
PNG
(US10793563, Compound I-10 | US10793563, Compound I...)
Show SMILES FC(F)(F)c1ccc2ncc(-c3ccnc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464690
PNG
(US10793563, Compound I-12)
Show SMILES FC(F)(F)c1ccc2ncc(-c3cccc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464706
PNG
(US10793563, Compound I-28)
Show SMILES Clc1ccc2ncc(-c3nccc(n3)N3CCNC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464687
PNG
(US10793563, Compound I-10 | US10793563, Compound I...)
Show SMILES FC(F)(F)c1ccc2ncc(-c3ccnc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464728
PNG
(US10793563, Compound I-50 | US10793563, Compound I...)
Show SMILES CC1CC(C(C)N(C1)c1ccnc(n1)-c1cnc2ccc(Cl)cn12)C(N)=O
Show InChI InChI=1S/C19H21ClN6O/c1-11-7-14(18(21)27)12(2)25(9-11)17-5-6-22-19(24-17)15-8-23-16-4-3-13(20)10-26(15)16/h3-6,8,10-12,14H,7,9H2,1-2H3,(H2,21,27)
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464759
PNG
(US10793563, Compound I-96)
Show SMILES Clc1ccc2ncc(-c3nccc(n3)N3CCN4C(CCNC4=O)C3)n2c1
Show InChI InChI=1S/C18H18ClN7O/c19-12-1-2-15-22-9-14(26(15)10-12)17-20-6-4-16(23-17)24-7-8-25-13(11-24)3-5-21-18(25)27/h1-2,4,6,9-10,13H,3,5,7-8,11H2,(H,21,27)
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464766
PNG
(US10793563, Compound I-103)
Show SMILES C[C@H]1CN(C[C@@H](CNS(C)(=O)=O)C1(F)F)c1nc(ns1)-c1cnc2ccc(cn12)C(F)F
Show InChI InChI=1S/C18H20F4N6O2S2/c1-10-7-27(9-12(18(10,21)22)5-24-32(2,29)30)17-25-16(26-31-17)13-6-23-14-4-3-11(15(19)20)8-28(13)14/h3-4,6,8,10,12,15,24H,5,7,9H2,1-2H3/t10-,12+/m0/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464781
PNG
(US10793563, Compound I-117 | US10793563, Compound ...)
Show SMILES C[C@@H]1CN(C[C@@H](O1)c1cn[nH]c1)c1nccc(n1)-c1cnc2ccc(cn12)C(F)(F)F
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464778
PNG
(US10793563, Compound I-114 | US10793563, Compound ...)
Show SMILES C[C@H]1C[C@H](CN(C1)c1nccc(n1)-c1cnc2ccc(cn12)C(F)(F)F)c1cn[nH]c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464695
PNG
(US10793563, Compound I-17)
Show SMILES CS(=O)(=O)NC[C@@H]1CN(CCO1)c1nccc(n1)-c1cnc2ccc(cn12)C(F)F
Show InChI InChI=1S/C18H20F2N6O3S/c1-30(27,28)23-8-13-11-25(6-7-29-13)18-21-5-4-14(24-18)15-9-22-16-3-2-12(17(19)20)10-26(15)16/h2-5,9-10,13,17,23H,6-8,11H2,1H3/t13-/m1/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464774
PNG
(US10793563, Compound I-110)
Show SMILES CS(=O)(=O)NCC1CCCN(C1)c1nsc(n1)-c1cnc2ccc(cn12)C(F)(F)F
Show InChI InChI=1S/C17H19F3N6O2S2/c1-30(27,28)22-7-11-3-2-6-25(9-11)16-23-15(29-24-16)13-8-21-14-5-4-12(10-26(13)14)17(18,19)20/h4-5,8,10-11,22H,2-3,6-7,9H2,1H3
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464777
PNG
(US10793563, Compound I-113)
Show SMILES CS(=O)(=O)NC[C@@H]1CN(CCO1)c1cncc(n1)-c1cnc2ccc(Cl)cn12
Show InChI InChI=1S/C17H19ClN6O3S/c1-28(25,26)21-6-13-11-23(4-5-27-13)17-9-19-7-14(22-17)15-8-20-16-3-2-12(18)10-24(15)16/h2-3,7-10,13,21H,4-6,11H2,1H3/t13-/m1/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464779
PNG
(US10793563, Compound I-115)
Show SMILES C[C@@H]1CN(C[C@@H](O1)c1cn[nH]c1C)c1nccc(n1)-c1cnc2ccc(cn12)C(F)(F)F
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464680
PNG
(US10793563, Compound I-2 | US10793563, Compound I-...)
Show SMILES FC(F)(F)c1ccc2ncc(-c3nccc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464696
PNG
(US10793563, Compound I-18)
Show SMILES FC(F)c1ccc2ncc(-c3ccnc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464732
PNG
(US10793563, Compound I-54 | US10793563, Compound I...)
Show SMILES C[C@@H]1CN(C[C@@H](O1)c1nc(C)no1)c1ccnc(n1)-c1cnc2ccc(Cl)cn12
Show InChI InChI=1S/C19H18ClN7O2/c1-11-8-26(10-15(28-11)19-23-12(2)25-29-19)17-5-6-21-18(24-17)14-7-22-16-4-3-13(20)9-27(14)16/h3-7,9,11,15H,8,10H2,1-2H3/t11-,15-/m1/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464763
PNG
(US10793563, Compound I-100)
Show SMILES Clc1ccc2ncc(-c3nccc(n3)N3CCCC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464764
PNG
(US10793563, Compound I-101)
Show SMILES FC(F)(F)c1ccc2ncc(-c3nccc(n3)N3CCCC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464770
PNG
(US10793563, Compound I-107)
Show SMILES CS(=O)(=O)NC[C@@H]1CN(CCO1)c1nc(ns1)-c1cnc2ccc(cn12)C(F)F
Show InChI InChI=1S/C16H18F2N6O3S2/c1-29(25,26)20-6-11-9-23(4-5-27-11)16-21-15(22-28-16)12-7-19-13-3-2-10(14(17)18)8-24(12)13/h2-3,7-8,11,14,20H,4-6,9H2,1H3/t11-/m1/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464776
PNG
(US10793563, Compound I-112)
Show SMILES CS(=O)(=O)NCC1CCCN(C1)c1nc(ns1)-c1cnc2ccc(cn12)C(F)(F)F
Show InChI InChI=1S/C17H19F3N6O2S2/c1-30(27,28)22-7-11-3-2-6-25(9-11)16-23-15(24-29-16)13-8-21-14-5-4-12(10-26(13)14)17(18,19)20/h4-5,8,10-11,22H,2-3,6-7,9H2,1H3
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464786
PNG
(US10793563, Compound I-154)
Show SMILES NC(=O)[C@H]1CCCN(C1)c1ccnc(n1)-c1cnc2ccc(cn12)C(F)(F)F
Show InChI InChI=1S/C18H17F3N6O/c19-18(20,21)12-3-4-14-24-8-13(27(14)10-12)17-23-6-5-15(25-17)26-7-1-2-11(9-26)16(22)28/h3-6,8,10-11H,1-2,7,9H2,(H2,22,28)/t11-/m0/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464788
PNG
(US10793563, Compound I-202)
Show SMILES NC(=O)C1CN(CC(F)(F)C1)c1ccnc(n1)-c1cnc2ccc(cn12)C(F)(F)F
Show InChI InChI=1S/C18H15F5N6O/c19-17(20)5-10(15(24)30)7-28(9-17)14-3-4-25-16(27-14)12-6-26-13-2-1-11(8-29(12)13)18(21,22)23/h1-4,6,8,10H,5,7,9H2,(H2,24,30)
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464702
PNG
(US10793563, Compound I-24)
Show SMILES Fc1cc2ncc(-c3nccc(n3)N3CCOC(C3)c3c[nH]cn3)n2cc1Br
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464715
PNG
(US10793563, Compound I-37)
Show SMILES C[C@H]1CN([C@@H](C)[C@H](N1)c1cn[nH]c1)c1ccnc(n1)-c1cnc2ccc(cn12)C(F)(F)F
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464720
PNG
(US10793563, Compound I-42)
Show SMILES CC1CN(C(C)C(N1)c1c[nH]cn1)c1nccc(n1)-c1cnc2cc(F)c(Cl)cn12
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464680
PNG
(US10793563, Compound I-2 | US10793563, Compound I-...)
Show SMILES FC(F)(F)c1ccc2ncc(-c3nccc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464687
PNG
(US10793563, Compound I-10 | US10793563, Compound I...)
Show SMILES FC(F)(F)c1ccc2ncc(-c3ccnc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464691
PNG
(US10793563, Compound I-13)
Show SMILES CS(=O)(=O)NC[C@@H]1CN(CCO1)c1ccnc(n1)-c1cnc2ccc(cn12)C(F)F
Show InChI InChI=1S/C18H20F2N6O3S/c1-30(27,28)23-8-13-11-25(6-7-29-13)16-4-5-21-18(24-16)14-9-22-15-3-2-12(17(19)20)10-26(14)15/h2-5,9-10,13,17,23H,6-8,11H2,1H3/t13-/m1/s1
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464693
PNG
(US10793563, Compound I-15)
Show SMILES FC(F)c1ccc2ncc(-c3nccc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464698
PNG
(US10793563, Compound I-20)
Show SMILES Clc1ccc2ncc(-c3nccc(n3)N3CCOC(C3)c3cn[nH]c3)n2c1
PDB
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464724
PNG
(US10793563, Compound I-46 | US10793563, Compound I...)
Show SMILES CC1CC(CS(C)(=N)=O)C(C)N(C1)c1ccnc(n1)-c1cnc2ccc(Cl)cn12
Show InChI InChI=1S/C20H25ClN6OS/c1-13-8-15(12-29(3,22)28)14(2)26(10-13)19-6-7-23-20(25-19)17-9-24-18-5-4-16(21)11-27(17)18/h4-7,9,11,13-15,22H,8,10,12H2,1-3H3
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464730
PNG
(US10793563, Compound I-52 | US10793563, Compound I...)
Show SMILES CC1CC(C(C)N(C1)c1ccnc(n1)-c1cnc2cc(F)c(Cl)cn12)C(N)=O
Show InChI InChI=1S/C19H20ClFN6O/c1-10-5-12(18(22)28)11(2)26(8-10)16-3-4-23-19(25-16)15-7-24-17-6-14(21)13(20)9-27(15)17/h3-4,6-7,9-12H,5,8H2,1-2H3,(H2,22,28)
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MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 4


(Homo sapiens (Human))
BDBM464755
PNG
(US10793563, Compound I-92)
Show SMILES C[C@@H]1CN(C[C@@H](O1)c1nc(C)no1)c1ccnc(n1)-c1cnc2ccc(cn12)C#N
Show InChI InChI=1S/C20H18N8O2/c1-12-9-27(11-16(29-12)20-24-13(2)26-30-20)18-5-6-22-19(25-18)15-8-23-17-4-3-14(7-21)10-28(15)17/h3-6,8,10,12,16H,9,11H2,1-2H3/t12-,16-/m1/s1
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<10n/an/an/an/an/an/an/an/a



MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
An assay buffer containing GCN2 kinase and (RS)7 was prepared. 4.7 μL of this stock solution was placed per well of a black, low volume, 384-wel...


US Patent US10793563 (2020)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%