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Patent code US10793576

Compile Data Set for Download or QSAR
Found 128 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50357312
PNG
(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465837
PNG
(US10793576, Example 69)
Show SMILES CC1(C)[C@H]2CN([C@@H]([C@@H]12)c1nc(-c2ccc(cc2)C(=O)Nc2cc(Cl)ccn2)c2c(N)nccn12)C(=O)C=C
Show InChI InChI=1S/C28H26ClN7O2/c1-4-20(37)36-14-18-21(28(18,2)3)23(36)26-34-22(24-25(30)32-11-12-35(24)26)15-5-7-16(8-6-15)27(38)33-19-13-17(29)9-10-31-19/h4-13,18,21,23H,1,14H2,2-3H3,(H2,30,32)(H,31,33,38)/t18-,21-,23-/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465786
PNG
(US10793576, Example 18)
Show SMILES CC(=O)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H26N8O3/c1-3-22(38)36-19-14-20(35(15-19)16(2)37)24(36)27-33-23(25-26(29)31-12-13-34(25)27)17-7-9-18(10-8-17)28(39)32-21-6-4-5-11-30-21/h3-13,19-20,24H,1,14-15H2,2H3,(H2,29,31)(H,30,32,39)/t19?,20-,24?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465822
PNG
(US10793576, Example 54)
Show SMILES CN1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C28H25F3N8O2/c1-3-21(40)39-18-13-19(37(2)14-18)23(39)26-36-22(24-25(32)34-10-11-38(24)26)15-4-6-16(7-5-15)27(41)35-20-12-17(8-9-33-20)28(29,30)31/h3-12,18-19,23H,1,13-14H2,2H3,(H2,32,34)(H,33,35,41)/t18?,19-,23?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465821
PNG
(US10793576, Example 53)
Show SMILES CC#CC(=O)N1C2CN[C@@H](C2)C1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C28H23F3N8O2/c1-2-3-21(40)39-18-13-19(35-14-18)23(39)26-37-22(24-25(32)34-10-11-38(24)26)15-4-6-16(7-5-15)27(41)36-20-12-17(8-9-33-20)28(29,30)31/h4-12,18-19,23,35H,13-14H2,1H3,(H2,32,34)(H,33,36,41)/t18?,19-,23?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465816
PNG
(US10793576, Example 48)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C12CCC(COC1)N2C(=O)C=C
Show InChI InChI=1S/C28H24F3N7O3/c1-2-21(39)38-19-7-9-27(38,15-41-14-19)26-36-22(23-24(32)34-11-12-37(23)26)16-3-5-17(6-4-16)25(40)35-20-13-18(8-10-33-20)28(29,30)31/h2-6,8,10-13,19H,1,7,9,14-15H2,(H2,32,34)(H,33,35,40)
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465823
PNG
(US10793576, Example 55)
Show SMILES CC(C)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C30H29F3N8O2/c1-4-23(42)41-20-14-21(40(15-20)16(2)3)25(41)28-38-24(26-27(34)36-11-12-39(26)28)17-5-7-18(8-6-17)29(43)37-22-13-19(9-10-35-22)30(31,32)33/h4-13,16,20-21,25H,1,14-15H2,2-3H3,(H2,34,36)(H,35,37,43)/t20?,21-,25?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465838
PNG
(US10793576, Example 70)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(Cl)ccn3)c12)C1[C@H]2CCC(C2)N1C(=O)C=C
Show InChI InChI=1S/C27H24ClN7O2/c1-2-21(36)35-19-8-7-17(13-19)23(35)26-33-22(24-25(29)31-11-12-34(24)26)15-3-5-16(6-4-15)27(37)32-20-14-18(28)9-10-30-20/h2-6,9-12,14,17,19,23H,1,7-8,13H2,(H2,29,31)(H,30,32,37)/t17-,19?,23?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465820
PNG
(US10793576, Example 52)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C1[C@@H]2CC(CN2)N1C(=O)C=C
Show InChI InChI=1S/C27H23F3N8O2/c1-2-20(39)38-17-12-18(34-13-17)22(38)25-36-21(23-24(31)33-9-10-37(23)25)14-3-5-15(6-4-14)26(40)35-19-11-16(7-8-32-19)27(28,29)30/h2-11,17-18,22,34H,1,12-13H2,(H2,31,33)(H,32,35,40)/t17?,18-,22?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465779
PNG
(US10793576, Example 11)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C12CCC(COC1)N2C(=O)C=C
Show InChI InChI=1S/C27H25N7O3/c1-2-21(35)34-19-10-11-27(34,16-37-15-19)26-32-22(23-24(28)30-13-14-33(23)26)17-6-8-18(9-7-17)25(36)31-20-5-3-4-12-29-20/h2-9,12-14,19H,1,10-11,15-16H2,(H2,28,30)(H,29,31,36)
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465865
PNG
(US10793576, Example 97)
Show SMILES CC#CC(=O)N1CC2CCCC2C1c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C29H27N5O2/c1-2-7-24(35)34-18-20-8-6-11-23(20)26(34)29-32-25(27-28(30)31-16-17-33(27)29)19-12-14-22(15-13-19)36-21-9-4-3-5-10-21/h3-5,9-10,12-17,20,23,26H,6,8,11,18H2,1H3,(H2,30,31)
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465777
PNG
(US10793576, Example 9)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C12COC(CN1C(=O)C=C)C2
Show InChI InChI=1S/C26H23N7O3/c1-2-20(34)33-14-18-13-26(33,15-36-18)25-31-21(22-23(27)29-11-12-32(22)25)16-6-8-17(9-7-16)24(35)30-19-5-3-4-10-28-19/h2-12,18H,1,13-15H2,(H2,27,29)(H,28,30,35)
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465864
PNG
(US10793576, Example 96)
Show SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1C2CCCC2CN1C(=O)C=C
Show InChI InChI=1S/C28H27N5O2/c1-2-23(34)33-17-19-7-6-10-22(19)25(33)28-31-24(26-27(29)30-15-16-32(26)28)18-11-13-21(14-12-18)35-20-8-4-3-5-9-20/h2-5,8-9,11-16,19,22,25H,1,6-7,10,17H2,(H2,29,30)
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465790
PNG
(4-(3-((1R,3S,4S)-2-acryloyl-2-azabicyclo[2.2.1]hep...)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1[C@H]2CC[C@H](C2)N1C(=O)C=C
Show InChI InChI=1S/C27H25N7O2/c1-2-21(35)34-19-11-10-18(15-19)23(34)26-32-22(24-25(28)30-13-14-33(24)26)16-6-8-17(9-7-16)27(36)31-20-5-3-4-12-29-20/h2-9,12-14,18-19,23H,1,10-11,15H2,(H2,28,30)(H,29,31,36)/t18-,19+,23?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465781
PNG
(US10793576, Example 13)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1[C@@H]2CC(CN2)N1C(=O)C=C
Show InChI InChI=1S/C26H24N8O2/c1-2-20(35)34-17-13-18(30-14-17)22(34)25-32-21(23-24(27)29-11-12-33(23)25)15-6-8-16(9-7-15)26(36)31-19-5-3-4-10-28-19/h2-12,17-18,22,30H,1,13-14H2,(H2,27,29)(H,28,31,36)/t17?,18-,22?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465861
PNG
(Preparation of (S)-1-(6-(8-amino-1-(4-phenoxypheny...)
Show SMILES CC#CC(=O)N1CC2(CC2)CC1c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N5O2/c1-2-6-23(34)33-18-28(13-14-28)17-22(33)27-31-24(25-26(29)30-15-16-32(25)27)19-9-11-21(12-10-19)35-20-7-4-3-5-8-20/h3-5,7-12,15-16,22H,13-14,17-18H2,1H3,(H2,29,30)
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465814
PNG
(US10793576, Example 46)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C1[C@H]2CCC(C2)N1C(=O)C=C
Show InChI InChI=1S/C28H24F3N7O2/c1-2-21(39)38-19-8-7-17(13-19)23(38)26-36-22(24-25(32)34-11-12-37(24)26)15-3-5-16(6-4-15)27(40)35-20-14-18(9-10-33-20)28(29,30)31/h2-6,9-12,14,17,19,23H,1,7-8,13H2,(H2,32,34)(H,33,35,40)/t17-,19?,23?/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465824
PNG
(US10793576, Example 56)
Show SMILES CC(=O)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C29H25F3N8O3/c1-3-22(42)40-19-13-20(39(14-19)15(2)41)24(40)27-37-23(25-26(33)35-10-11-38(25)27)16-4-6-17(7-5-16)28(43)36-21-12-18(8-9-34-21)29(30,31)32/h3-12,19-20,24H,1,13-14H2,2H3,(H2,33,35)(H,34,36,43)/t19?,20-,24?/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465860
PNG
(US10793576, Example 92)
Show SMILES CC#CC(=O)N1C2C[C@@H](C1c1nc(-c3ccc(cc3)C(C)(O)c3ccccc3)c3c(N)nccn13)N(C2)C(C)C
Show InChI InChI=1S/C32H34N6O2/c1-5-9-26(39)38-24-18-25(37(19-24)20(2)3)28(38)31-35-27(29-30(33)34-16-17-36(29)31)21-12-14-23(15-13-21)32(4,40)22-10-7-6-8-11-22/h6-8,10-17,20,24-25,28,40H,18-19H2,1-4H3,(H2,33,34)/t24?,25-,28?,32?/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465811
PNG
(US10793576, Example 43)
Show SMILES CC#CC(=O)N1CC2CCCC2C1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C30H26F3N7O2/c1-2-4-23(41)40-16-19-5-3-6-21(19)25(40)28-38-24(26-27(34)36-13-14-39(26)28)17-7-9-18(10-8-17)29(42)37-22-15-20(11-12-35-22)30(31,32)33/h7-15,19,21,25H,3,5-6,16H2,1H3,(H2,34,36)(H,35,37,42)
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n/an/a 4.40n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465894
PNG
(Preparation of (1 S,4S)-tert-butyl-5-acryloyl-6-(8...)
Show SMILES CC1CN([C@@H](C)C(N1C(=O)C=C)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C32H36N8O4/c1-7-24(41)40-19(2)18-39(31(43)44-32(4,5)6)20(3)26(40)29-37-25(27-28(33)35-16-17-38(27)29)21-11-13-22(14-12-21)30(42)36-23-10-8-9-15-34-23/h7-17,19-20,26H,1,18H2,2-6H3,(H2,33,35)(H,34,36,42)/t19?,20-,26?/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465772
PNG
(US10793576, Example 4)
Show SMILES CC#CC(=O)N1CC2CCCC2C1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C29H27N7O2/c1-2-6-23(37)36-17-20-7-5-8-21(20)25(36)28-34-24(26-27(30)32-15-16-35(26)28)18-10-12-19(13-11-18)29(38)33-22-9-3-4-14-31-22/h3-4,9-16,20-21,25H,5,7-8,17H2,1H3,(H2,30,32)(H,31,33,38)
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n/an/a 4.5n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465881
PNG
(Preparation of 4-(8-amino-3-((1S)-2-((E)-4-(dimeth...)
Show SMILES CN(C)C\C=C\C(=O)N1CC2CCCC2[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C31H34N8O2/c1-37(2)17-6-10-25(40)39-19-22-7-5-8-23(22)27(39)30-36-26(28-29(32)34-16-18-38(28)30)20-11-13-21(14-12-20)31(41)35-24-9-3-4-15-33-24/h3-4,6,9-16,18,22-23,27H,5,7-8,17,19H2,1-2H3,(H2,32,34)(H,33,35,41)/b10-6+/t22?,23?,27-/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465872
PNG
(US10793576, Example 104)
Show SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)C12CCC(COC1)N2C(=O)C=C
Show InChI InChI=1S/C27H25N5O3/c1-2-22(33)32-19-12-13-27(32,17-34-16-19)26-30-23(24-25(28)29-14-15-31(24)26)18-8-10-21(11-9-18)35-20-6-4-3-5-7-20/h2-11,14-15,19H,1,12-13,16-17H2,(H2,28,29)
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n/an/a 4.60n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465771
PNG
(US10793576, Example 3)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1C2CCCC2CN1C(=O)C=C
Show InChI InChI=1S/C28H27N7O2/c1-2-22(36)35-16-19-6-5-7-20(19)24(35)27-33-23(25-26(29)31-14-15-34(25)27)17-9-11-18(12-10-17)28(37)32-21-8-3-4-13-30-21/h2-4,8-15,19-20,24H,1,5-7,16H2,(H2,29,31)(H,30,32,37)
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n/an/a 4.70n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465817
PNG
(US10793576, Example 49)
Show SMILES CC#CC(=O)N1C2CCC1(COC2)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C29H24F3N7O3/c1-2-3-22(40)39-20-8-10-28(39,16-42-15-20)27-37-23(24-25(33)35-12-13-38(24)27)17-4-6-18(7-5-17)26(41)36-21-14-19(9-11-34-21)29(30,31)32/h4-7,9,11-14,20H,8,10,15-16H2,1H3,(H2,33,35)(H,34,36,41)
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n/an/a 4.80n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465847
PNG
(US10793576, Example 79)
Show SMILES CC(O)(c1ccccc1)c1ccc(cc1)-c1nc(C2[C@H]3CCC(C3)N2C(=O)C=C)n2ccnc(N)c12
Show InChI InChI=1S/C29H29N5O2/c1-3-23(35)34-22-14-11-19(17-22)25(34)28-32-24(26-27(30)31-15-16-33(26)28)18-9-12-21(13-10-18)29(2,36)20-7-5-4-6-8-20/h3-10,12-13,15-16,19,22,25,36H,1,11,14,17H2,2H3,(H2,30,31)/t19-,22?,25?,29?/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465815
PNG
(US10793576, Example 47)
Show SMILES CC#CC(=O)N1C2CC[C@@H](C2)C1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C29H24F3N7O2/c1-2-3-22(40)39-20-9-8-18(14-20)24(39)27-37-23(25-26(33)35-12-13-38(25)27)16-4-6-17(7-5-16)28(41)36-21-15-19(10-11-34-21)29(30,31)32/h4-7,10-13,15,18,20,24H,8-9,14H2,1H3,(H2,33,35)(H,34,36,41)/t18-,20?,24?/m0/s1
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n/an/a 5.20n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465810
PNG
(US10793576, Example 42)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C1C2CCCC2CN1C(=O)C=C
Show InChI InChI=1S/C29H26F3N7O2/c1-2-22(40)39-15-18-4-3-5-20(18)24(39)27-37-23(25-26(33)35-12-13-38(25)27)16-6-8-17(9-7-16)28(41)36-21-14-19(10-11-34-21)29(30,31)32/h2,6-14,18,20,24H,1,3-5,15H2,(H2,33,35)(H,34,36,41)
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n/an/a 5.30n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465836
PNG
(US10793576, Example 68)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(Cl)ccn3)c12)C1C2CCCC2CN1C(=O)C=C
Show InChI InChI=1S/C28H26ClN7O2/c1-2-22(37)36-15-18-4-3-5-20(18)24(36)27-34-23(25-26(30)32-12-13-35(25)27)16-6-8-17(9-7-16)28(38)33-21-14-19(29)10-11-31-21/h2,6-14,18,20,24H,1,3-5,15H2,(H2,30,32)(H,31,33,38)
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n/an/a 5.30n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465886
PNG
(Preparation of 4-(3-((1R,2S,4S)-7-acryloyl-7-azabi...)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@H]1CC2CCC1N2C(=O)C=C
Show InChI InChI=1S/C27H25N7O2/c1-2-22(35)34-18-10-11-20(34)19(15-18)26-32-23(24-25(28)30-13-14-33(24)26)16-6-8-17(9-7-16)27(36)31-21-5-3-4-12-29-21/h2-9,12-14,18-20H,1,10-11,15H2,(H2,28,30)(H,29,31,36)/t18?,19-,20?/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465862
PNG
(US10793576, Example 94 | US10793576, Example 95)
Show SMILES Cc1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C19H16N4O/c1-13-22-17(18-19(20)21-11-12-23(13)18)14-7-9-16(10-8-14)24-15-5-3-2-4-6-15/h2-12H,1H3,(H2,20,21)
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n/an/a 7.20n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465845
PNG
(US10793576, Example 77)
Show SMILES CC(O)(c1ccccc1)c1ccc(cc1)-c1nc(C2C3CCCC3CN2C(=O)C=C)n2ccnc(N)c12
Show InChI InChI=1S/C30H31N5O2/c1-3-24(36)35-18-20-8-7-11-23(20)26(35)29-33-25(27-28(31)32-16-17-34(27)29)19-12-14-22(15-13-19)30(2,37)21-9-5-4-6-10-21/h3-6,9-10,12-17,20,23,26,37H,1,7-8,11,18H2,2H3,(H2,31,32)
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n/an/a 8.5n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465774
PNG
(US10793576, Example 6)
Show SMILES CC#CC(=O)N1C[C@H]2[C@@H]([C@H]1c1nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c3c(N)nccn13)C2(C)C
Show InChI InChI=1S/C29H27N7O2/c1-4-7-21(37)36-16-19-22(29(19,2)3)24(36)27-34-23(25-26(30)32-14-15-35(25)27)17-9-11-18(12-10-17)28(38)33-20-8-5-6-13-31-20/h5-6,8-15,19,22,24H,16H2,1-3H3,(H2,30,32)(H,31,33,38)/t19-,22-,24-/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465853
PNG
(US10793576, Example 85)
Show SMILES CC#CC(=O)N1C2CCC1(COC2)c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C30H29N5O3/c1-3-7-24(36)35-23-14-15-30(35,19-38-18-23)28-33-25(26-27(31)32-16-17-34(26)28)20-10-12-22(13-11-20)29(2,37)21-8-5-4-6-9-21/h4-6,8-13,16-17,23,37H,14-15,18-19H2,1-2H3,(H2,31,32)
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n/an/a 9.40n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465784
PNG
(US10793576, Example 16)
Show SMILES CC(C)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C29H30N8O2/c1-4-23(38)37-20-15-21(36(16-20)17(2)3)25(37)28-34-24(26-27(30)32-13-14-35(26)28)18-8-10-19(11-9-18)29(39)33-22-7-5-6-12-31-22/h4-14,17,20-21,25H,1,15-16H2,2-3H3,(H2,30,32)(H,31,33,39)/t20?,21-,25?/m0/s1
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n/an/a 9.5n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465839
PNG
(US10793576, Example 71)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(Cl)ccn3)c12)C1CC2CC2N1C(=O)C=C
Show InChI InChI=1S/C26H22ClN7O2/c1-2-21(35)34-18-11-16(18)12-19(34)25-32-22(23-24(28)30-9-10-33(23)25)14-3-5-15(6-4-14)26(36)31-20-13-17(27)7-8-29-20/h2-10,13,16,18-19H,1,11-12H2,(H2,28,30)(H,29,31,36)
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n/an/a 12n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465782
PNG
(US10793576, Example 14)
Show SMILES CC#CC(=O)N1C2CN[C@@H](C2)C1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C27H24N8O2/c1-2-5-21(36)35-18-14-19(31-15-18)23(35)26-33-22(24-25(28)30-12-13-34(24)26)16-7-9-17(10-8-16)27(37)32-20-6-3-4-11-29-20/h3-4,6-13,18-19,23,31H,14-15H2,1H3,(H2,28,30)(H,29,32,37)/t18?,19-,23?/m0/s1
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n/an/a 12.5n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465830
PNG
(US10793576, Example 62)
Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc(C3[C@H]4CCC(C4)N3C(=O)C=C)n3ccnc(N)c23)c1
Show InChI InChI=1S/C28H27N7O2/c1-3-22(36)35-20-9-8-19(15-20)24(35)27-33-23(25-26(29)31-12-13-34(25)27)17-4-6-18(7-5-17)28(37)32-21-14-16(2)10-11-30-21/h3-7,10-14,19-20,24H,1,8-9,15H2,2H3,(H2,29,31)(H,30,32,37)/t19-,20?,24?/m0/s1
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n/an/a 13n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465857
PNG
(US10793576, Example 89 | US10793576, Example 91)
Show SMILES CC(C)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C31H34N6O2/c1-5-25(38)37-23-17-24(36(18-23)19(2)3)27(37)30-34-26(28-29(32)33-15-16-35(28)30)20-11-13-22(14-12-20)31(4,39)21-9-7-6-8-10-21/h5-16,19,23-24,27,39H,1,17-18H2,2-4H3,(H2,32,33)/t23?,24-,27?,31?/m0/s1
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n/an/a 14n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465780
PNG
(US10793576, Example 12)
Show SMILES CC#CC(=O)N1C2CCC1(COC2)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O3/c1-2-5-22(36)35-20-11-12-28(35,17-38-16-20)27-33-23(24-25(29)31-14-15-34(24)27)18-7-9-19(10-8-18)26(37)32-21-6-3-4-13-30-21/h3-4,6-10,13-15,20H,11-12,16-17H2,1H3,(H2,29,31)(H,30,32,37)
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n/an/a 14n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465862
PNG
(US10793576, Example 94 | US10793576, Example 95)
Show SMILES Cc1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C19H16N4O/c1-13-22-17(18-19(20)21-11-12-23(13)18)14-7-9-16(10-8-14)24-15-5-3-2-4-6-15/h2-12H,1H3,(H2,20,21)
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n/an/a 14.3n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465852
PNG
(US10793576, Example 84)
Show SMILES CC(O)(c1ccccc1)c1ccc(cc1)-c1nc(n2ccnc(N)c12)C12CCC(COC1)N2C(=O)C=C
Show InChI InChI=1S/C29H29N5O3/c1-3-23(35)34-22-13-14-29(34,18-37-17-22)27-32-24(25-26(30)31-15-16-33(25)27)19-9-11-21(12-10-19)28(2,36)20-7-5-4-6-8-20/h3-12,15-16,22,36H,1,13-14,17-18H2,2H3,(H2,30,31)
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n/an/a 16.3n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465813
PNG
(US10793576, Example 45)
Show SMILES CC#CC(=O)N1C[C@H]2[C@@H](C1c1nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c3c(N)nccn13)C2(C)C
Show InChI InChI=1S/C30H26F3N7O2/c1-4-5-21(41)40-15-19-22(29(19,2)3)24(40)27-38-23(25-26(34)36-12-13-39(25)27)16-6-8-17(9-7-16)28(42)37-20-14-18(10-11-35-20)30(31,32)33/h6-14,19,22,24H,15H2,1-3H3,(H2,34,36)(H,35,37,42)/t19-,22-,24?/m0/s1
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n/an/a 17n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465783
PNG
(US10793576, Example 15)
Show SMILES CN1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C27H26N8O2/c1-3-21(36)35-18-14-19(33(2)15-18)23(35)26-32-22(24-25(28)30-12-13-34(24)26)16-7-9-17(10-8-16)27(37)31-20-6-4-5-11-29-20/h3-13,18-19,23H,1,14-15H2,2H3,(H2,28,30)(H,29,31,37)/t18?,19-,23?/m0/s1
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n/an/a 17.4n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465892
PNG
(Preparation of (S)-3-(3-(5-acryloyl-5-azaspiro[2.4...)
Show SMILES Nc1nccn2c(nc(-c3cccc(c3)C(=O)Nc3ccccn3)c12)C1CC2(CC2)CN1C(=O)C=C
Show InChI InChI=1S/C27H25N7O2/c1-2-21(35)34-16-27(9-10-27)15-19(34)25-32-22(23-24(28)30-12-13-33(23)25)17-6-5-7-18(14-17)26(36)31-20-8-3-4-11-29-20/h2-8,11-14,19H,1,9-10,15-16H2,(H2,28,30)(H,29,31,36)
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n/an/a 18n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465841
PNG
(US10793576, Example 73)
Show SMILES CC#CC(=O)N1C2CC2CC1c1nc(-c2ccc(cc2)C(=O)Nc2cc(Cl)ccn2)c2c(N)nccn12
Show InChI InChI=1S/C27H22ClN7O2/c1-2-3-22(36)35-19-12-17(19)13-20(35)26-33-23(24-25(29)31-10-11-34(24)26)15-4-6-16(7-5-15)27(37)32-21-14-18(28)8-9-30-21/h4-11,14,17,19-20H,12-13H2,1H3,(H2,29,31)(H,30,32,37)
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n/an/a 18n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465873
PNG
(US10793576, Example 105)
Show SMILES CC#CC(=O)N1C2CCC1(COC2)c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N5O3/c1-2-6-23(34)33-20-13-14-28(33,18-35-17-20)27-31-24(25-26(29)30-15-16-32(25)27)19-9-11-22(12-10-19)36-21-7-4-3-5-8-21/h3-5,7-12,15-16,20H,13-14,17-18H2,1H3,(H2,29,30)
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n/an/a 18n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465846
PNG
(US10793576, Example 78)
Show SMILES CC#CC(=O)N1CC2CCCC2C1c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C31H31N5O2/c1-3-8-25(37)36-19-21-9-7-12-24(21)27(36)30-34-26(28-29(32)33-17-18-35(28)30)20-13-15-23(16-14-20)31(2,38)22-10-5-4-6-11-22/h4-6,10-11,13-18,21,24,27,38H,7,9,12,19H2,1-2H3,(H2,32,33)
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n/an/a 18.4n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465877
PNG
(US10793576, Example 109)
Show SMILES CC(C)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C29H30N6O2/c1-4-24(36)35-20-16-23(34(17-20)18(2)3)26(35)29-32-25(27-28(30)31-14-15-33(27)29)19-10-12-22(13-11-19)37-21-8-6-5-7-9-21/h4-15,18,20,23,26H,1,16-17H2,2-3H3,(H2,30,31)/t20?,23-,26?/m0/s1
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n/an/a 19n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465857
PNG
(US10793576, Example 89 | US10793576, Example 91)
Show SMILES CC(C)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C31H34N6O2/c1-5-25(38)37-23-17-24(36(18-23)19(2)3)27(37)30-34-26(28-29(32)33-15-16-35(28)30)20-11-13-22(14-12-20)31(4,39)21-9-7-6-8-10-21/h5-16,19,23-24,27,39H,1,17-18H2,2-4H3,(H2,32,33)/t23?,24-,27?,31?/m0/s1
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n/an/a 21n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465773
PNG
(US10793576, Example 5)
Show SMILES CC1(C)[C@H]2CN([C@@H]([C@@H]12)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12)C(=O)C=C
Show InChI InChI=1S/C28H27N7O2/c1-4-20(36)35-15-18-21(28(18,2)3)23(35)26-33-22(24-25(29)31-13-14-34(24)26)16-8-10-17(11-9-16)27(37)32-19-7-5-6-12-30-19/h4-14,18,21,23H,1,15H2,2-3H3,(H2,29,31)(H,30,32,37)/t18-,21-,23-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465880
PNG
(Preparation of (S,E)-4-(8-amino-3-(5-(4-(dimethyla...)
Show SMILES CN(C)C\C=C\C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C30H32N8O2/c1-36(2)16-5-7-24(39)38-19-30(12-13-30)18-22(38)28-35-25(26-27(31)33-15-17-37(26)28)20-8-10-21(11-9-20)29(40)34-23-6-3-4-14-32-23/h3-11,14-15,17,22H,12-13,16,18-19H2,1-2H3,(H2,31,33)(H,32,34,40)/b7-5+/t22-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465770
PNG
(US10793576, Example 2)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1CC2(CC2)CN1C(=O)C=C
Show InChI InChI=1S/C27H25N7O2/c1-2-21(35)34-16-27(10-11-27)15-19(34)25-32-22(23-24(28)30-13-14-33(23)25)17-6-8-18(9-7-17)26(36)31-20-5-3-4-12-29-20/h2-9,12-14,19H,1,10-11,15-16H2,(H2,28,30)(H,29,31,36)
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n/an/a 24n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465842
PNG
(Preparation of 1-((6S)-6-(8-amino-1-(4-(1-hydroxy-...)
Show SMILES CC(O)(c1ccccc1)c1ccc(cc1)-c1nc(C2CC3(CC3)CN2C(=O)C=C)n2ccnc(N)c12
Show InChI InChI=1S/C29H29N5O2/c1-3-23(35)34-18-29(13-14-29)17-22(34)27-32-24(25-26(30)31-15-16-33(25)27)19-9-11-21(12-10-19)28(2,36)20-7-5-4-6-8-20/h3-12,15-16,22,36H,1,13-14,17-18H2,2H3,(H2,30,31)
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n/an/a 24n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465888
PNG
(Preparation of 4-(3-(2-acryloyl-2-azabicyclo[2.2.2...)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C12CCC(CC1)CN2C(=O)C=C
Show InChI InChI=1S/C28H27N7O2/c1-2-22(36)35-17-18-10-12-28(35,13-11-18)27-33-23(24-25(29)31-15-16-34(24)27)19-6-8-20(9-7-19)26(37)32-21-5-3-4-14-30-21/h2-9,14-16,18H,1,10-13,17H2,(H2,29,31)(H,30,32,37)
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n/an/a 24n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465848
PNG
(US10793576, Example 80)
Show SMILES CC#CC(=O)N1C2CC[C@@H](C2)C1c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C30H29N5O2/c1-3-7-24(36)35-23-15-12-20(18-23)26(35)29-33-25(27-28(31)32-16-17-34(27)29)19-10-13-22(14-11-19)30(2,37)21-8-5-4-6-9-21/h4-6,8-11,13-14,16-17,20,23,26,37H,12,15,18H2,1-2H3,(H2,31,32)/t20-,23?,26?,30?/m0/s1
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n/an/a 24n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465866
PNG
(US10793576, Example 98)
Show SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1[C@H]2CCC(C2)N1C(=O)C=C
Show InChI InChI=1S/C27H25N5O2/c1-2-22(33)32-19-11-8-18(16-19)24(32)27-30-23(25-26(28)29-14-15-31(25)27)17-9-12-21(13-10-17)34-20-6-4-3-5-7-20/h2-7,9-10,12-15,18-19,24H,1,8,11,16H2,(H2,28,29)/t18-,19?,24?/m0/s1
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n/an/a 24n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465883
PNG
(Preparation of 4-(8-amino-3-((1S)-2-((E)-4-(cyclop...)
Show SMILES CN(C\C=C\C(=O)N1CC2CCCC2[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12)C1CC1
Show InChI InChI=1S/C33H36N8O2/c1-39(24-14-15-24)18-5-9-27(42)41-20-23-6-4-7-25(23)29(41)32-38-28(30-31(34)36-17-19-40(30)32)21-10-12-22(13-11-21)33(43)37-26-8-2-3-16-35-26/h2-3,5,8-13,16-17,19,23-25,29H,4,6-7,14-15,18,20H2,1H3,(H2,34,36)(H,35,37,43)/b9-5+/t23?,25?,29-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465854
PNG
(US10793576, Example 86)
Show SMILES CC(O)(c1ccccc1)c1ccc(cc1)-c1nc(C2[C@@H]3CC(CN3)N2C(=O)C=C)n2ccnc(N)c12
Show InChI InChI=1S/C28H28N6O2/c1-3-22(35)34-20-15-21(31-16-20)24(34)27-32-23(25-26(29)30-13-14-33(25)27)17-9-11-19(12-10-17)28(2,36)18-7-5-4-6-8-18/h3-14,20-21,24,31,36H,1,15-16H2,2H3,(H2,29,30)/t20?,21-,24?,28?/m0/s1
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n/an/a 29n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465879
PNG
(US10793576, Example 111)
Show SMILES CC#CC(=O)N1C2C[C@@H](C1c1nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)nccn13)N(C2)C(C)C
Show InChI InChI=1S/C30H30N6O2/c1-4-8-25(37)36-21-17-24(35(18-21)19(2)3)27(36)30-33-26(28-29(31)32-15-16-34(28)30)20-11-13-23(14-12-20)38-22-9-6-5-7-10-22/h5-7,9-16,19,21,24,27H,17-18H2,1-3H3,(H2,31,32)/t21?,24-,27?/m0/s1
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n/an/a 30n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465829
PNG
(US10793576, Example 61)
Show SMILES CC#CC(=O)N1C[C@H]2[C@@H]([C@H]1c1nc(-c3ccc(cc3)C(=O)Nc3cc(C)ccn3)c3c(N)nccn13)C2(C)C
Show InChI InChI=1S/C30H29N7O2/c1-5-6-22(38)37-16-20-23(30(20,3)4)25(37)28-35-24(26-27(31)33-13-14-36(26)28)18-7-9-19(10-8-18)29(39)34-21-15-17(2)11-12-32-21/h7-15,20,23,25H,16H2,1-4H3,(H2,31,33)(H,32,34,39)/t20-,23-,25-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465834
PNG
(US10793576, Example 66)
Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc(C3[C@@H]4CC(CN4)N3C(=O)C=C)n3ccnc(N)c23)c1
Show InChI InChI=1S/C27H26N8O2/c1-3-21(36)35-18-13-19(31-14-18)23(35)26-33-22(24-25(28)30-10-11-34(24)26)16-4-6-17(7-5-16)27(37)32-20-12-15(2)8-9-29-20/h3-12,18-19,23,31H,1,13-14H2,2H3,(H2,28,30)(H,29,32,37)/t18?,19-,23?/m0/s1
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n/an/a 34n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465812
PNG
(US10793576, Example 44)
Show SMILES CC1(C)[C@H]2CN(C([C@@H]12)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12)C(=O)C=C
Show InChI InChI=1S/C29H26F3N7O2/c1-4-20(40)39-14-18-21(28(18,2)3)23(39)26-37-22(24-25(33)35-11-12-38(24)26)15-5-7-16(8-6-15)27(41)36-19-13-17(9-10-34-19)29(30,31)32/h4-13,18,21,23H,1,14H2,2-3H3,(H2,33,35)(H,34,36,41)/t18-,21-,23?/m0/s1
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n/an/a 34n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465878
PNG
(US10793576, Example 110)
Show SMILES CC(=O)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C28H26N6O3/c1-3-23(36)34-19-15-22(33(16-19)17(2)35)25(34)28-31-24(26-27(29)30-13-14-32(26)28)18-9-11-21(12-10-18)37-20-7-5-4-6-8-20/h3-14,19,22,25H,1,15-16H2,2H3,(H2,29,30)/t19?,22-,25?/m0/s1
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n/an/a 36n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465867
PNG
(US10793576, Example 99)
Show SMILES CC#CC(=O)N1C2CC[C@@H](C2)C1c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N5O2/c1-2-6-23(34)33-20-12-9-19(17-20)25(33)28-31-24(26-27(29)30-15-16-32(26)28)18-10-13-22(14-11-18)35-21-7-4-3-5-8-21/h3-5,7-8,10-11,13-16,19-20,25H,9,12,17H2,1H3,(H2,29,30)/t19-,20?,25?/m0/s1
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n/an/a 39n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465875
PNG
(US10793576, Example 107)
Show SMILES CC#CC(=O)N1C2CN[C@@H](C2)C1c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C27H24N6O2/c1-2-6-22(34)33-18-15-21(30-16-18)24(33)27-31-23(25-26(28)29-13-14-32(25)27)17-9-11-20(12-10-17)35-19-7-4-3-5-8-19/h3-5,7-14,18,21,24,30H,15-16H2,1H3,(H2,28,29)/t18?,21-,24?/m0/s1
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n/an/a 41n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465855
PNG
(US10793576, Example 87)
Show SMILES CC#CC(=O)N1C2CN[C@@H](C2)C1c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C29H28N6O2/c1-3-7-23(36)35-21-16-22(32-17-21)25(35)28-33-24(26-27(30)31-14-15-34(26)28)18-10-12-20(13-11-18)29(2,37)19-8-5-4-6-9-19/h4-6,8-15,21-22,25,32,37H,16-17H2,1-2H3,(H2,30,31)/t21?,22-,25?,29?/m0/s1
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n/an/a 42n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465889
PNG
(Preparation of 4-(8-amino-3-(2-(but-2-ynoyl)-2-aza...)
Show SMILES CC#CC(=O)N1CC2CCC1(CC2)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C29H27N7O2/c1-2-5-23(37)36-18-19-11-13-29(36,14-12-19)28-34-24(25-26(30)32-16-17-35(25)28)20-7-9-21(10-8-20)27(38)33-22-6-3-4-15-31-22/h3-4,6-10,15-17,19H,11-14,18H2,1H3,(H2,30,32)(H,31,33,38)
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n/an/a 43n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465887
PNG
(Preparation of 4-(8-amino-3-((1R,2S,4S)-7-(but-2-y...)
Show SMILES CC#CC(=O)N1C2CCC1[C@H](C2)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O2/c1-2-5-23(36)35-19-11-12-21(35)20(16-19)27-33-24(25-26(29)31-14-15-34(25)27)17-7-9-18(10-8-17)28(37)32-22-6-3-4-13-30-22/h3-4,6-10,13-15,19-21H,11-12,16H2,1H3,(H2,29,31)(H,30,32,37)/t19?,20-,21?/m0/s1
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n/an/a 43n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465805
PNG
(US10793576, Example 37)
Show SMILES CC#CC(=O)N1CC2(CC1c1nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c3c(N)nccn13)CCNCC2
Show InChI InChI=1S/C30H30N8O2/c1-2-5-24(39)38-19-30(11-14-32-15-12-30)18-22(38)28-36-25(26-27(31)34-16-17-37(26)28)20-7-9-21(10-8-20)29(40)35-23-6-3-4-13-33-23/h3-4,6-10,13,16-17,22,32H,11-12,14-15,18-19H2,1H3,(H2,31,34)(H,33,35,40)
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n/an/a 46n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465844
PNG
(US10793576, Example 76)
Show SMILES CC#CC(=O)N1C[C@H]2[C@@H]([C@H]1c1nc(-c3ccc(cc3)C(C)(O)c3ccccc3)c3c(N)nccn13)C2(C)C
Show InChI InChI=1S/C31H31N5O2/c1-5-9-23(37)36-18-22-24(30(22,2)3)26(36)29-34-25(27-28(32)33-16-17-35(27)29)19-12-14-21(15-13-19)31(4,38)20-10-7-6-8-11-20/h6-8,10-17,22,24,26,38H,18H2,1-4H3,(H2,32,33)/t22-,24-,26-,31?/m0/s1
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n/an/a 46n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465851
PNG
(US10793576, Example 83)
Show SMILES CC#CC(=O)N1CCC2CC12c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C29H27N5O2/c1-3-7-23(35)34-16-14-22-18-29(22,34)27-32-24(25-26(30)31-15-17-33(25)27)19-10-12-21(13-11-19)28(2,36)20-8-5-4-6-9-20/h4-6,8-13,15,17,22,36H,14,16,18H2,1-2H3,(H2,30,31)
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n/an/a 46n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465874
PNG
(US10793576, Example 106)
Show SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1[C@@H]2CC(CN2)N1C(=O)C=C
Show InChI InChI=1S/C26H24N6O2/c1-2-21(33)32-17-14-20(29-15-17)23(32)26-30-22(24-25(27)28-12-13-31(24)26)16-8-10-19(11-9-16)34-18-6-4-3-5-7-18/h2-13,17,20,23,29H,1,14-15H2,(H2,27,28)/t17?,20-,23?/m0/s1
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n/an/a 47n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50175583
PNG
(ACALABRUTINIB | ACP-196 | Acalabrutinib | US102398...)
Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465785
PNG
(US10793576, Example 17)
Show SMILES CC#CC(=O)N1C2C[C@@H](C1c1nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c3c(N)nccn13)N(C2)C(C)C
Show InChI InChI=1S/C30H30N8O2/c1-4-7-24(39)38-21-16-22(37(17-21)18(2)3)26(38)29-35-25(27-28(31)33-14-15-36(27)29)19-9-11-20(12-10-19)30(40)34-23-8-5-6-13-32-23/h5-6,8-15,18,21-22,26H,16-17H2,1-3H3,(H2,31,33)(H,32,34,40)/t21?,22-,26?/m0/s1
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n/an/a 48n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465890
PNG
(Preparation of 4-(3-(2-acryloyl-2-azabicyclo[2.2.1...)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C12CCC(CN1C(=O)C=C)C2
Show InChI InChI=1S/C27H25N7O2/c1-2-21(35)34-16-17-10-11-27(34,15-17)26-32-22(23-24(28)30-13-14-33(23)26)18-6-8-19(9-7-18)25(36)31-20-5-3-4-12-29-20/h2-9,12-14,17H,1,10-11,15-16H2,(H2,28,30)(H,29,31,36)
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n/an/a 49n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465791
PNG
(US10793576, Example 23)
Show SMILES CC#CC(=O)N1[C@@H]2CC[C@@H](C2)C1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O2/c1-2-5-22(36)35-20-12-11-19(16-20)24(35)27-33-23(25-26(29)31-14-15-34(25)27)17-7-9-18(10-8-17)28(37)32-21-6-3-4-13-30-21/h3-4,6-10,13-15,19-20,24H,11-12,16H2,1H3,(H2,29,31)(H,30,32,37)/t19-,20+,24?/m0/s1
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n/an/a 49n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465856
PNG
(US10793576, Example 88)
Show SMILES CN1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C29H30N6O2/c1-4-23(36)35-21-16-22(33(3)17-21)25(35)28-32-24(26-27(30)31-14-15-34(26)28)18-10-12-20(13-11-18)29(2,37)19-8-6-5-7-9-19/h4-15,21-22,25,37H,1,16-17H2,2-3H3,(H2,30,31)/t21?,22-,25?,29?/m0/s1
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n/an/a 51n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465828
PNG
(US10793576, Example 60)
Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3[C@@H]4[C@H](CN3C(=O)C=C)C4(C)C)n3ccnc(N)c23)c1
Show InChI InChI=1S/C29H29N7O2/c1-5-21(37)36-15-19-22(29(19,3)4)24(36)27-34-23(25-26(30)32-12-13-35(25)27)17-6-8-18(9-7-17)28(38)33-20-14-16(2)10-11-31-20/h5-14,19,22,24H,1,15H2,2-4H3,(H2,30,32)(H,31,33,38)/t19-,22-,24-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465809
PNG
(Preparation of (S)-4-(3-(5-acryloyl-5-azaspiro[2.4...)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C1CC2(CC2)CN1C(=O)C=C
Show InChI InChI=1S/C28H24F3N7O2/c1-2-21(39)38-15-27(8-9-27)14-19(38)25-36-22(23-24(32)34-11-12-37(23)25)16-3-5-17(6-4-16)26(40)35-20-13-18(7-10-33-20)28(29,30)31/h2-7,10-13,19H,1,8-9,14-15H2,(H2,32,34)(H,33,35,40)
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n/an/a 52n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465819
PNG
(US10793576, Example 51)
Show SMILES CC#CC(=O)N1C2CC2CC1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C28H22F3N7O2/c1-2-3-22(39)38-19-12-17(19)13-20(38)26-36-23(24-25(32)34-10-11-37(24)26)15-4-6-16(7-5-15)27(40)35-21-14-18(8-9-33-21)28(29,30)31/h4-11,14,17,19-20H,12-13H2,1H3,(H2,32,34)(H,33,35,40)
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n/an/a 54n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465831
PNG
(US10793576, Example 63)
Show SMILES CC#CC(=O)N1C2CC[C@@H](C2)C1c1nc(-c2ccc(cc2)C(=O)Nc2cc(C)ccn2)c2c(N)nccn12
Show InChI InChI=1S/C29H27N7O2/c1-3-4-23(37)36-21-10-9-20(16-21)25(36)28-34-24(26-27(30)32-13-14-35(26)28)18-5-7-19(8-6-18)29(38)33-22-15-17(2)11-12-31-22/h5-8,11-15,20-21,25H,9-10,16H2,1-2H3,(H2,30,32)(H,31,33,38)/t20-,21?,25?/m0/s1
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n/an/a 57n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465843
PNG
(US10793576, Example 75)
Show SMILES CC(O)(c1ccccc1)c1ccc(cc1)-c1nc([C@@H]2[C@@H]3[C@H](CN2C(=O)C=C)C3(C)C)n2ccnc(N)c12
Show InChI InChI=1S/C30H31N5O2/c1-5-22(36)35-17-21-23(29(21,2)3)25(35)28-33-24(26-27(31)32-15-16-34(26)28)18-11-13-20(14-12-18)30(4,37)19-9-7-6-8-10-19/h5-16,21,23,25,37H,1,17H2,2-4H3,(H2,31,32)/t21-,23-,25-,30?/m0/s1
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n/an/a 57n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465800
PNG
(US10793576, Example 32)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C12CC1CCN2C(=O)C=C
Show InChI InChI=1S/C26H23N7O2/c1-2-20(34)33-13-10-18-15-26(18,33)25-31-21(22-23(27)29-12-14-32(22)25)16-6-8-17(9-7-16)24(35)30-19-5-3-4-11-28-19/h2-9,11-12,14,18H,1,10,13,15H2,(H2,27,29)(H,28,30,35)
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n/an/a 57n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465893
PNG
(Preparation of (S)-2-(3-(5-acryloyl-5-azaspiro[2.4...)
Show SMILES Nc1nccn2c(nc(-c3ccccc3C(=O)Nc3ccccn3)c12)C1CC2(CC2)CN1C(=O)C=C
Show InChI InChI=1S/C27H25N7O2/c1-2-21(35)34-16-27(10-11-27)15-19(34)25-32-22(23-24(28)30-13-14-33(23)25)17-7-3-4-8-18(17)26(36)31-20-9-5-6-12-29-20/h2-9,12-14,19H,1,10-11,15-16H2,(H2,28,30)(H,29,31,36)
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n/an/a 58n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465833
PNG
(US10793576, Example 65)
Show SMILES CC#CC(=O)N1C2CC2CC1c1nc(-c2ccc(cc2)C(=O)Nc2cc(C)ccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O2/c1-3-4-23(36)35-20-14-19(20)15-21(35)27-33-24(25-26(29)31-11-12-34(25)27)17-5-7-18(8-6-17)28(37)32-22-13-16(2)9-10-30-22/h5-13,19-21H,14-15H2,1-2H3,(H2,29,31)(H,30,32,37)
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n/an/a 58n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465825
PNG
(US10793576, Example 57)
Show SMILES CC#CC(=O)N1C2C[C@@H](C1c1nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c3c(N)nccn13)N(C2)C(C)C
Show InChI InChI=1S/C31H29F3N8O2/c1-4-5-24(43)42-21-15-22(41(16-21)17(2)3)26(42)29-39-25(27-28(35)37-12-13-40(27)29)18-6-8-19(9-7-18)30(44)38-23-14-20(10-11-36-23)31(32,33)34/h6-14,17,21-22,26H,15-16H2,1-3H3,(H2,35,37)(H,36,38,44)/t21?,22-,26?/m0/s1
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n/an/a 59n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465802
PNG
(US10793576, Example 34)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C12CCC1CN(C2)C(=O)C=C
Show InChI InChI=1S/C27H25N7O2/c1-2-21(35)33-15-19-10-11-27(19,16-33)26-32-22(23-24(28)30-13-14-34(23)26)17-6-8-18(9-7-17)25(36)31-20-5-3-4-12-29-20/h2-9,12-14,19H,1,10-11,15-16H2,(H2,28,30)(H,29,31,36)
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n/an/a 66n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465806
PNG
(US10793576, Example 38)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@]12COCC1CN(C2)C(=O)C=C
Show InChI InChI=1S/C27H25N7O3/c1-2-21(35)33-13-19-14-37-16-27(19,15-33)26-32-22(23-24(28)30-11-12-34(23)26)17-6-8-18(9-7-17)25(36)31-20-5-3-4-10-29-20/h2-12,19H,1,13-16H2,(H2,28,30)(H,29,31,36)/t19?,27-/m1/s1
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n/an/a 66n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465868
PNG
(US10793576, Example 100)
Show SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CC2CC2N1C(=O)C=C
Show InChI InChI=1S/C26H23N5O2/c1-2-22(32)31-20-14-17(20)15-21(31)26-29-23(24-25(27)28-12-13-30(24)26)16-8-10-19(11-9-16)33-18-6-4-3-5-7-18/h2-13,17,20-21H,1,14-15H2,(H2,27,28)
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n/an/a 67n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465803
PNG
(US10793576, Example 35)
Show SMILES CC#CC(=O)N1CC2CCC2(C1)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O2/c1-2-5-22(36)34-16-20-11-12-28(20,17-34)27-33-23(24-25(29)31-14-15-35(24)27)18-7-9-19(10-8-18)26(37)32-21-6-3-4-13-30-21/h3-4,6-10,13-15,20H,11-12,16-17H2,1H3,(H2,29,31)(H,30,32,37)
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n/an/a 67n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465807
PNG
(US10793576, Example 39)
Show SMILES CC#CC(=O)N1CC2COC[C@@]2(C1)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O3/c1-2-5-22(36)34-14-20-15-38-17-28(20,16-34)27-33-23(24-25(29)31-12-13-35(24)27)18-7-9-19(10-8-18)26(37)32-21-6-3-4-11-30-21/h3-4,6-13,20H,14-17H2,1H3,(H2,29,31)(H,30,32,37)/t20?,28-/m1/s1
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n/an/a 68n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465818
PNG
(US10793576, Example 50)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C1CC2CC2N1C(=O)C=C
Show InChI InChI=1S/C27H22F3N7O2/c1-2-21(38)37-18-11-16(18)12-19(37)25-35-22(23-24(31)33-9-10-36(23)25)14-3-5-15(6-4-14)26(39)34-20-13-17(7-8-32-20)27(28,29)30/h2-10,13,16,18-19H,1,11-12H2,(H2,31,33)(H,32,34,39)
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n/an/a 69n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465835
PNG
(US10793576, Example 67)
Show SMILES CC#CC(=O)N1C2CN[C@@H](C2)C1c1nc(-c2ccc(cc2)C(=O)Nc2cc(C)ccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H26N8O2/c1-3-4-22(37)36-19-14-20(32-15-19)24(36)27-34-23(25-26(29)31-11-12-35(25)27)17-5-7-18(8-6-17)28(38)33-21-13-16(2)9-10-30-21/h5-13,19-20,24,32H,14-15H2,1-2H3,(H2,29,31)(H,30,33,38)/t19?,20-,24?/m0/s1
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n/an/a 69n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465876
PNG
(US10793576, Example 108)
Show SMILES CN1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C27H26N6O2/c1-3-22(34)33-18-15-21(31(2)16-18)24(33)27-30-23(25-26(28)29-13-14-32(25)27)17-9-11-20(12-10-17)35-19-7-5-4-6-8-19/h3-14,18,21,24H,1,15-16H2,2H3,(H2,28,29)/t18?,21-,24?/m0/s1
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n/an/a 72n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465778
PNG
(US10793576, Example 10)
Show SMILES CC#CC(=O)N1CC2CC1(CO2)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C27H23N7O3/c1-2-5-21(35)34-15-19-14-27(34,16-37-19)26-32-22(23-24(28)30-12-13-33(23)26)17-7-9-18(10-8-17)25(36)31-20-6-3-4-11-29-20/h3-4,6-13,19H,14-16H2,1H3,(H2,28,30)(H,29,31,36)
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n/an/a 72n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465891
PNG
(Preparation of 4-(8-amino-3-(2-(but-2-ynoyl)-2-aza...)
Show SMILES CC#CC(=O)N1CC2CCC1(C2)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O2/c1-2-5-22(36)35-17-18-11-12-28(35,16-18)27-33-23(24-25(29)31-14-15-34(24)27)19-7-9-20(10-8-19)26(37)32-21-6-3-4-13-30-21/h3-4,6-10,13-15,18H,11-12,16-17H2,1H3,(H2,29,31)(H,30,32,37)
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n/an/a 72n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465869
PNG
(US10793576, Example 101)
Show SMILES CC#CC(=O)N1C2CC2CC1c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C27H23N5O2/c1-2-6-23(33)32-21-15-18(21)16-22(32)27-30-24(25-26(28)29-13-14-31(25)27)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-14,18,21-22H,15-16H2,1H3,(H2,28,29)
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n/an/a 77n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465826
PNG
(US10793576, Example 58)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C12CC1CCN2C(=O)C=C
Show InChI InChI=1S/C27H22F3N7O2/c1-2-20(38)37-11-8-18-14-26(18,37)25-35-21(22-23(31)33-10-12-36(22)25)15-3-5-16(6-4-15)24(39)34-19-13-17(7-9-32-19)27(28,29)30/h2-7,9-10,12-13,18H,1,8,11,14H2,(H2,31,33)(H,32,34,39)
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n/an/a 78n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465858
PNG
(US10793576, Example 90)
Show SMILES CC(=O)N1CC2C[C@H]1C(N2C(=O)C=C)c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C30H30N6O3/c1-4-24(38)36-22-16-23(35(17-22)18(2)37)26(36)29-33-25(27-28(31)32-14-15-34(27)29)19-10-12-21(13-11-19)30(3,39)20-8-6-5-7-9-20/h4-15,22-23,26,39H,1,16-17H2,2-3H3,(H2,31,32)/t22?,23-,26?,30?/m0/s1
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CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465882
PNG
(US10793576, Example 114)
Show SMILES CN(C\C=C\C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12)C1CC1
Show InChI InChI=1S/C32H34N8O2/c1-38(23-11-12-23)17-4-6-26(41)40-20-32(13-14-32)19-24(40)30-37-27(28-29(33)35-16-18-39(28)30)21-7-9-22(10-8-21)31(42)36-25-5-2-3-15-34-25/h2-10,15-16,18,23-24H,11-14,17,19-20H2,1H3,(H2,33,35)(H,34,36,42)/b6-4+/t24-/m0/s1
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n/an/a 81n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465769
PNG
(US10793576, Example 1)
Show SMILES CC#CC(=O)N1CC2(CC2)CC1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O2/c1-2-5-22(36)35-17-28(11-12-28)16-20(35)26-33-23(24-25(29)31-14-15-34(24)26)18-7-9-19(10-8-18)27(37)32-21-6-3-4-13-30-21/h3-4,6-10,13-15,20H,11-12,16-17H2,1H3,(H2,29,31)(H,30,32,37)
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n/an/a 83n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465832
PNG
(US10793576, Example 64)
Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc(C3CC4CC4N3C(=O)C=C)n3ccnc(N)c23)c1
Show InChI InChI=1S/C27H25N7O2/c1-3-22(35)34-19-13-18(19)14-20(34)26-32-23(24-25(28)30-10-11-33(24)26)16-4-6-17(7-5-16)27(36)31-21-12-15(2)8-9-29-21/h3-12,18-20H,1,13-14H2,2H3,(H2,28,30)(H,29,31,36)
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n/an/a 87n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465804
PNG
(US10793576, Example 36)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1CC2(CN1C(=O)C=C)CCNCC2
Show InChI InChI=1S/C29H30N8O2/c1-2-23(38)37-18-29(10-13-31-14-11-29)17-21(37)27-35-24(25-26(30)33-15-16-36(25)27)19-6-8-20(9-7-19)28(39)34-22-5-3-4-12-32-22/h2-9,12,15-16,21,31H,1,10-11,13-14,17-18H2,(H2,30,33)(H,32,34,39)
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n/an/a 93n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465801
PNG
(US10793576, Example 33)
Show SMILES CC#CC(=O)N1CCC2CC12c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C27H23N7O2/c1-2-5-21(35)34-14-11-19-16-27(19,34)26-32-22(23-24(28)30-13-15-33(23)26)17-7-9-18(10-8-17)25(36)31-20-6-3-4-12-29-20/h3-4,6-10,12-13,15,19H,11,14,16H2,1H3,(H2,28,30)(H,29,31,36)
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n/an/a 94n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465827
PNG
(US10793576, Example 59)
Show SMILES CC#CC(=O)N1CCC2CC12c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C28H22F3N7O2/c1-2-3-21(39)38-12-9-19-15-27(19,38)26-36-22(23-24(32)34-11-13-37(23)26)16-4-6-17(7-5-16)25(40)35-20-14-18(8-10-33-20)28(29,30)31/h4-8,10-11,13-14,19H,9,12,15H2,1H3,(H2,32,34)(H,33,35,40)
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n/an/a 97n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465808
PNG
((S)-4-(8-amino-3-(5-(but-2-ynoyl)-5-azaspiro[2.4]h...)
Show SMILES CC#CC(=O)N1CC2(CC2)CC1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
Show InChI InChI=1S/C29H24F3N7O2/c1-2-3-22(40)39-16-28(9-10-28)15-20(39)26-37-23(24-25(33)35-12-13-38(24)26)17-4-6-18(7-5-17)27(41)36-21-14-19(8-11-34-21)29(30,31)32/h4-8,11-14,20H,9-10,15-16H2,1H3,(H2,33,35)(H,34,36,41)
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n/an/a 97n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465840
PNG
(US10793576, Example 72)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(Cl)ccn3)c12)C1[C@@H]2CC(CN2)N1C(=O)C=C
Show InChI InChI=1S/C26H23ClN8O2/c1-2-20(36)35-17-12-18(31-13-17)22(35)25-33-21(23-24(28)30-9-10-34(23)25)14-3-5-15(6-4-14)26(37)32-19-11-16(27)7-8-29-19/h2-11,17-18,22,31H,1,12-13H2,(H2,28,30)(H,29,32,37)/t17?,18-,22?/m0/s1
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n/an/a 97n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465885
PNG
(Preparation of 4-(8-amino-3-((1S)-2-((Z)-2-cyano-4...)
Show SMILES CC(C)\C=C(\C#N)C(=O)N1CC2CCCC2[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C32H32N8O2/c1-19(2)16-23(17-33)32(42)40-18-22-6-5-7-24(22)27(40)30-38-26(28-29(34)36-14-15-39(28)30)20-9-11-21(12-10-20)31(41)37-25-8-3-4-13-35-25/h3-4,8-16,19,22,24,27H,5-7,18H2,1-2H3,(H2,34,36)(H,35,37,41)/b23-16-/t22?,24?,27-/m0/s1
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n/an/a 104n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465796
PNG
(US10793576, Example 28)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C12CC3CC(CC(C3)(C1)NC(=O)C=C)C2
Show InChI InChI=1S/C31H31N7O2/c1-2-24(39)37-31-16-19-13-20(17-31)15-30(14-19,18-31)29-36-25(26-27(32)34-11-12-38(26)29)21-6-8-22(9-7-21)28(40)35-23-5-3-4-10-33-23/h2-12,19-20H,1,13-18H2,(H2,32,34)(H,37,39)(H,33,35,40)
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n/an/a 124n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465775
PNG
(US10793576, Example 7)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C12C[C@@H](CN1C(=O)C=C)OCC2
Show InChI InChI=1S/C27H25N7O3/c1-2-21(35)34-16-19-15-27(34,10-14-37-19)26-32-22(23-24(28)30-12-13-33(23)26)17-6-8-18(9-7-17)25(36)31-20-5-3-4-11-29-20/h2-9,11-13,19H,1,10,14-16H2,(H2,28,30)(H,29,31,36)/t19-,27?/m0/s1
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n/an/a 155n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465870
PNG
(US10793576, Example 102)
Show SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4)cc3)c12)C12CC1CCN2C(=O)C=C
Show InChI InChI=1S/C26H23N5O2/c1-2-21(32)31-14-12-18-16-26(18,31)25-29-22(23-24(27)28-13-15-30(23)25)17-8-10-20(11-9-17)33-19-6-4-3-5-7-19/h2-11,13,15,18H,1,12,14,16H2,(H2,27,28)
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n/an/a 175n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465792
PNG
(US10793576, Example 24)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1CC2CC2N1C(=O)C=C
Show InChI InChI=1S/C26H23N7O2/c1-2-21(34)33-18-13-17(18)14-19(33)25-31-22(23-24(27)29-11-12-32(23)25)15-6-8-16(9-7-15)26(35)30-20-5-3-4-10-28-20/h2-12,17-19H,1,13-14H2,(H2,27,29)(H,28,30,35)
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n/an/a 176n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465849
PNG
(US10793576, Example 81)
Show SMILES CC(O)(c1ccccc1)c1ccc(cc1)-c1nc(C2CC3CC3N2C(=O)C=C)n2ccnc(N)c12
Show InChI InChI=1S/C28H27N5O2/c1-3-23(34)33-21-15-18(21)16-22(33)27-31-24(25-26(29)30-13-14-32(25)27)17-9-11-20(12-10-17)28(2,35)19-7-5-4-6-8-19/h3-14,18,21-22,35H,1,15-16H2,2H3,(H2,29,30)
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n/an/a 178n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465776
PNG
(US10793576, Example 8)
Show SMILES CC#CC(=O)N1C[C@@H]2CC1(CCO2)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C28H25N7O3/c1-2-5-22(36)35-17-20-16-28(35,11-15-38-20)27-33-23(24-25(29)31-13-14-34(24)27)18-7-9-19(10-8-18)26(37)32-21-6-3-4-12-30-21/h3-4,6-10,12-14,20H,11,15-17H2,1H3,(H2,29,31)(H,30,32,37)/t20-,28?/m0/s1
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n/an/a 197n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465797
PNG
(US10793576, Example 29)
Show SMILES CC#CC(=O)NC12CC3CC(C1)CC(C3)(C2)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C32H31N7O2/c1-2-5-25(40)38-32-17-20-14-21(18-32)16-31(15-20,19-32)30-37-26(27-28(33)35-12-13-39(27)30)22-7-9-23(10-8-22)29(41)36-24-6-3-4-11-34-24/h3-4,6-13,20-21H,14-19H2,1H3,(H2,33,35)(H,38,40)(H,34,36,41)
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n/an/a 216n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465871
PNG
(US10793576, Example 103)
Show SMILES CC#CC(=O)N1CCC2CC12c1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)nccn12
Show InChI InChI=1S/C27H23N5O2/c1-2-6-22(33)32-15-13-19-17-27(19,32)26-30-23(24-25(28)29-14-16-31(24)26)18-9-11-21(12-10-18)34-20-7-4-3-5-8-20/h3-5,7-12,14,16,19H,13,15,17H2,1H3,(H2,28,29)
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n/an/a 271n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465884
PNG
(US10793576, Example 116)
Show SMILES CC(C)\C=C(\C#N)C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C31H30N8O2/c1-19(2)15-22(17-32)30(41)39-18-31(10-11-31)16-23(39)28-37-25(26-27(33)35-13-14-38(26)28)20-6-8-21(9-7-20)29(40)36-24-5-3-4-12-34-24/h3-9,12-15,19,23H,10-11,16,18H2,1-2H3,(H2,33,35)(H,34,36,40)/b22-15-/t23-/m0/s1
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n/an/a 276n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465793
PNG
(US10793576, Example 25)
Show SMILES CC#CC(=O)N1C2CC2CC1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C27H23N7O2/c1-2-5-22(35)34-19-14-18(19)15-20(34)26-32-23(24-25(28)30-12-13-33(24)26)16-7-9-17(10-8-16)27(36)31-21-6-3-4-11-29-21/h3-4,6-13,18-20H,14-15H2,1H3,(H2,28,30)(H,29,31,36)
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n/an/a 342n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465788
PNG
(US10793576, Example 20)
Show SMILES CC(=O)N1C2C[C@@H](C1c1nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c3c(N)nccn13)N(C2)C(=O)C=C
Show InChI InChI=1S/C28H26N8O3/c1-3-22(38)35-15-19-14-20(35)24(36(19)16(2)37)27-33-23(25-26(29)31-12-13-34(25)27)17-7-9-18(10-8-17)28(39)32-21-6-4-5-11-30-21/h3-13,19-20,24H,1,14-15H2,2H3,(H2,29,31)(H,30,32,39)/t19?,20-,24?/m0/s1
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n/an/a 372n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465850
PNG
(US10793576, Example 82)
Show SMILES CC#CC(=O)N1C2CC2CC1c1nc(-c2ccc(cc2)C(C)(O)c2ccccc2)c2c(N)nccn12
Show InChI InChI=1S/C29H27N5O2/c1-3-7-24(35)34-22-16-19(22)17-23(34)28-32-25(26-27(30)31-14-15-33(26)28)18-10-12-21(13-11-18)29(2,36)20-8-5-4-6-9-20/h4-6,8-15,19,22-23,36H,16-17H2,1-2H3,(H2,30,31)
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n/an/a 382n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465787
PNG
(US10793576, Example 19)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1NC2C[C@@H]1N(C2)C(=O)C=C
Show InChI InChI=1S/C26H24N8O2/c1-2-20(35)34-14-17-13-18(34)22(30-17)25-32-21(23-24(27)29-11-12-33(23)25)15-6-8-16(9-7-15)26(36)31-19-5-3-4-10-28-19/h2-12,17-18,22,30H,1,13-14H2,(H2,27,29)(H,28,31,36)/t17?,18-,22?/m0/s1
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n/an/a 400n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465794
PNG
(US10793576, Example 26)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1COC2(C1)CCN(CC2)C(=O)C=C
Show InChI InChI=1S/C29H29N7O3/c1-2-23(37)35-14-10-29(11-15-35)17-21(18-39-29)27-34-24(25-26(30)32-13-16-36(25)27)19-6-8-20(9-7-19)28(38)33-22-5-3-4-12-31-22/h2-9,12-13,16,21H,1,10-11,14-15,17-18H2,(H2,30,32)(H,31,33,38)
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n/an/a 477n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465789
PNG
(US10793576, Example 21)
Show SMILES CC#CC(=O)N1CC2C[C@H]1C(N2)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Show InChI InChI=1S/C27H24N8O2/c1-2-5-21(36)35-15-18-14-19(35)23(31-18)26-33-22(24-25(28)30-12-13-34(24)26)16-7-9-17(10-8-16)27(37)32-20-6-3-4-11-29-20/h3-4,6-13,18-19,23,31H,14-15H2,1H3,(H2,28,30)(H,29,32,37)/t18?,19-,23?/m0/s1
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n/an/a 672n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465795
PNG
(US10793576, Example 27)
Show SMILES CC#CC(=O)N1CCC2(CC(CO2)c2nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c3c(N)nccn23)CC1
Show InChI InChI=1S/C30H29N7O3/c1-2-5-24(38)36-15-11-30(12-16-36)18-22(19-40-30)28-35-25(26-27(31)33-14-17-37(26)28)20-7-9-21(10-8-20)29(39)34-23-6-3-4-13-32-23/h3-4,6-10,13-14,17,22H,11-12,15-16,18-19H2,1H3,(H2,31,33)(H,32,34,39)
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n/an/a 673n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465798
PNG
(US10793576, Example 30)
Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)C1CC11CCN(C1)C(=O)C=C
Show InChI InChI=1S/C27H25N7O2/c1-2-21(35)33-13-10-27(16-33)15-19(27)25-32-22(23-24(28)30-12-14-34(23)25)17-6-8-18(9-7-17)26(36)31-20-5-3-4-11-29-20/h2-9,11-12,14,19H,1,10,13,15-16H2,(H2,28,30)(H,29,31,36)
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n/an/a 724n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM465799
PNG
(US10793576, Example 31)
Show SMILES CC#CC(=O)N1CCC2(CC2c2nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c3c(N)nccn23)C1
Show InChI InChI=1S/C28H25N7O2/c1-2-5-22(36)34-14-11-28(17-34)16-20(28)26-33-23(24-25(29)31-13-15-35(24)26)18-7-9-19(10-8-18)27(37)32-21-6-3-4-12-30-21/h3-4,6-10,12-13,15,20H,11,14,16-17H2,1H3,(H2,29,31)(H,30,32,37)
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n/an/a 736n/an/an/an/an/an/a



CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1: Test Principle:Mobility-Shift Assay, which is microfluidic chip technology, applies the basic concept of capillary electrophoresis to microfluidic...


US Patent US10793576 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%