BindingDB logo
myBDB logout

Patent code US10800775

Compile Data Set for Download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466938
PNG
(US10800775, Example 18 | isopropyl 4-(1-(2-cyano-1...)
Show SMILES CC(C)OC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent


Assay Description
The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...


US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466934
PNG
(US10800775, Example 1 | ethyl 4-(1-(2-cyano-1-cycl...)
Show SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)C(CC#N)C1CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent


Assay Description
The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...


US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466936
PNG
(US10800775, Example 16 | ethyl 4-(1-(2-cyano-1-cyc...)
Show SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent


Assay Description
The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...


US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466935
PNG
(US10800775, Example 9 | ethyl 4-(1-(3-(cyanomethyl...)
Show SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)C1(CC#N)CN(C1)S(=O)(=O)CC
Show InChI InChI=1S/C20H22N6O4S/c1-3-30-19(27)16-10-23-18-15(5-8-22-18)17(16)14-9-24-26(11-14)20(6-7-21)12-25(13-20)31(28,29)4-2/h5,8-11H,3-4,6,12-13H2,1-2H3,(H,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent


Assay Description
The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...


US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466940
PNG
(US10800775, Example 20 | propyl (R)-4-(1-(2-cyano-...)
Show SMILES CCCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent


Assay Description
The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...


US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466939
PNG
(US10800775, Example 19 | isopropyl 4-(1-(2-cyano-1...)
Show SMILES CC(C)OC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@@H](CC#N)C1CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent


Assay Description
The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...


US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM466939
PNG
(US10800775, Example 19 | isopropyl 4-(1-(2-cyano-1...)
Show SMILES CC(C)OC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@@H](CC#N)C1CCCC1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent




US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM466935
PNG
(US10800775, Example 9 | ethyl 4-(1-(3-(cyanomethyl...)
Show SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)C1(CC#N)CN(C1)S(=O)(=O)CC
Show InChI InChI=1S/C20H22N6O4S/c1-3-30-19(27)16-10-23-18-15(5-8-22-18)17(16)14-9-24-26(11-14)20(6-7-21)12-25(13-20)31(28,29)4-2/h5,8-11H,3-4,6,12-13H2,1-2H3,(H,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent




US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM466937
PNG
(US10800775, Example 17 | ethyl 4-(1-(2-cyano-1-cyc...)
Show SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@@H](CC#N)C1CCCC1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent




US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM466940
PNG
(US10800775, Example 20 | propyl (R)-4-(1-(2-cyano-...)
Show SMILES CCCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent




US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM466938
PNG
(US10800775, Example 18 | isopropyl 4-(1-(2-cyano-1...)
Show SMILES CC(C)OC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent




US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM466937
PNG
(US10800775, Example 17 | ethyl 4-(1-(2-cyano-1-cyc...)
Show SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@@H](CC#N)C1CCCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent


Assay Description
The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...


US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM466934
PNG
(US10800775, Example 1 | ethyl 4-(1-(2-cyano-1-cycl...)
Show SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)C(CC#N)C1CCCC1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent




US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM466936
PNG
(US10800775, Example 16 | ethyl 4-(1-(2-cyano-1-cyc...)
Show SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)[C@H](CC#N)C1CCCC1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



ACLARIS THERAPEUTICS, INC.

US Patent




US Patent US10800775 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%