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Patent code US10899741

Compile Data Set for Download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM479981
PNG
(4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazo...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CCC1
Show InChI InChI=1S/C25H24N4O2S/c1-17-5-3-8-23(27-17)25-22(16-29(28-25)20-6-4-7-20)19-13-14-26-24(15-19)18-9-11-21(12-10-18)32(2,30)31/h3,5,8-16,20H,4,6-7H2,1-2H3
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n/an/a 208n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM480002
PNG
(4-(1-Cyclopentyl-3-(6-methylpyridin-2-yl)-1H-pyraz...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CCCC1
Show InChI InChI=1S/C26H26N4O2S/c1-18-6-5-9-24(28-18)26-23(17-30(29-26)21-7-3-4-8-21)20-14-15-27-25(16-20)19-10-12-22(13-11-19)33(2,31)32/h5-6,9-17,21H,3-4,7-8H2,1-2H3
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n/an/a 241n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM480001
PNG
(4-(1-Cyclopropyl-3-(6-methylpyridin-2-yl)-1H-pyraz...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CC1
Show InChI InChI=1S/C24H22N4O2S/c1-16-4-3-5-22(26-16)24-21(15-28(27-24)19-8-9-19)18-12-13-25-23(14-18)17-6-10-20(11-7-17)31(2,29)30/h3-7,10-15,19H,8-9H2,1-2H3
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n/an/a 270n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM480003
PNG
((R)-4-(3-(6-Methylpyridin-2-yl)-1-(1-(methylsulfon...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)[C@@H]1CCN(C1)S(C)(=O)=O
Show InChI InChI=1S/C26H27N5O4S2/c1-18-5-4-6-24(28-18)26-23(17-31(29-26)21-12-14-30(16-21)37(3,34)35)20-11-13-27-25(15-20)19-7-9-22(10-8-19)36(2,32)33/h4-11,13,15,17,21H,12,14,16H2,1-3H3/t21-/m1/s1
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n/an/a 370n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM480001
PNG
(4-(1-Cyclopropyl-3-(6-methylpyridin-2-yl)-1H-pyraz...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CC1
Show InChI InChI=1S/C24H22N4O2S/c1-16-4-3-5-22(26-16)24-21(15-28(27-24)19-8-9-19)18-12-13-25-23(14-18)17-6-10-20(11-7-17)31(2,29)30/h3-7,10-15,19H,8-9H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase RIPK2


(Homo sapiens (Human))
BDBM479981
PNG
(4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazo...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CCC1
Show InChI InChI=1S/C25H24N4O2S/c1-17-5-3-8-23(27-17)25-22(16-29(28-25)20-6-4-7-20)19-13-14-26-24(15-19)18-9-11-21(12-10-18)32(2,30)31/h3,5,8-16,20H,4,6-7H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
RIPK2 kinase assay kit (V4084, Promega) was used to assay enzyme activity. 2 μl of RIPK2 enzyme solution (the final concentration of enzyme in t...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM479981
PNG
(4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazo...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CCC1
Show InChI InChI=1S/C25H24N4O2S/c1-17-5-3-8-23(27-17)25-22(16-29(28-25)20-6-4-7-20)19-13-14-26-24(15-19)18-9-11-21(12-10-18)32(2,30)31/h3,5,8-16,20H,4,6-7H2,1-2H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM479981
PNG
(4-(1-Cyclobutyl-3-(6-methylpyridin-2-yl)-1H-pyrazo...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CCC1
Show InChI InChI=1S/C25H24N4O2S/c1-17-5-3-8-23(27-17)25-22(16-29(28-25)20-6-4-7-20)19-13-14-26-24(15-19)18-9-11-21(12-10-18)32(2,30)31/h3,5,8-16,20H,4,6-7H2,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
VEGFR2: Z'-LYTECŪ Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM480001
PNG
(4-(1-Cyclopropyl-3-(6-methylpyridin-2-yl)-1H-pyraz...)
Show SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CC1
Show InChI InChI=1S/C24H22N4O2S/c1-16-4-3-5-22(26-16)24-21(15-28(27-24)19-8-9-19)18-12-13-25-23(14-18)17-6-10-20(11-7-17)31(2,29)30/h3-7,10-15,19H,8-9H2,1-2H3
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n/an/a 4.20E+3n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
VEGFR2: Z'-LYTECŪ Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human...


US Patent US10899741 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%