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Patent code US10905687

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480767
PNG
(US10905687, Compound 31)
Show SMILES OCCOC(=O)CC1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C30H31F6N3O4/c31-29(32,33)28(42,30(34,35)36)25-7-5-24(6-8-25)23-3-1-21(2-4-23)18-38-13-14-39(19-22-9-11-37-12-10-22)26(20-38)17-27(41)43-16-15-40/h1-12,26,40,42H,13-20H2
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n/an/a<1.00E+3n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480768
PNG
(US10905687, Compound 32)
Show SMILES CCOCCOC(=O)CC1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C32H35F6N3O4/c1-2-44-17-18-45-29(42)19-28-22-40(15-16-41(28)21-24-11-13-39-14-12-24)20-23-3-5-25(6-4-23)26-7-9-27(10-8-26)30(43,31(33,34)35)32(36,37)38/h3-14,28,43H,2,15-22H2,1H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480760
PNG
(US10905687, Compound 17)
Show SMILES CCOC(=O)C1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C29H29F6N3O3/c1-2-41-26(39)25-19-37(15-16-38(25)18-21-11-13-36-14-12-21)17-20-3-5-22(6-4-20)23-7-9-24(10-8-23)27(40,28(30,31)32)29(33,34)35/h3-14,25,40H,2,15-19H2,1H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480761
PNG
(US10905687, Compound 18)
Show SMILES CCOC(=O)CC1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C30H31F6N3O3/c1-2-42-27(40)17-26-20-38(15-16-39(26)19-22-11-13-37-14-12-22)18-21-3-5-23(6-4-21)24-7-9-25(10-8-24)28(41,29(31,32)33)30(34,35)36/h3-14,26,41H,2,15-20H2,1H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480772
PNG
(US10905687, Compound 48)
Show SMILES CCOC(=O)C[C@H]1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C30H31F6N3O3/c1-2-42-27(40)17-26-20-38(15-16-39(26)19-22-11-13-37-14-12-22)18-21-3-5-23(6-4-21)24-7-9-25(10-8-24)28(41,29(31,32)33)30(34,35)36/h3-14,26,41H,2,15-20H2,1H3/t26-/m0/s1
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480771
PNG
(US10905687, Compound 47)
Show SMILES CCOC(=O)C[C@H]1CN(Cc2ccc(c(C)c2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C31H33F6N3O3/c1-3-43-28(41)17-26-20-39(14-15-40(26)19-22-10-12-38-13-11-22)18-23-4-9-27(21(2)16-23)24-5-7-25(8-6-24)29(42,30(32,33)34)31(35,36)37/h4-13,16,26,42H,3,14-15,17-20H2,1-2H3/t26-/m0/s1
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n/an/a<1.00E+3n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480766
PNG
(US10905687, Compound 30)
Show SMILES CC(C)OC(=O)CC1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C31H33F6N3O3/c1-21(2)43-28(41)17-27-20-39(15-16-40(27)19-23-11-13-38-14-12-23)18-22-3-5-24(6-4-22)25-7-9-26(10-8-25)29(42,30(32,33)34)31(35,36)37/h3-14,21,27,42H,15-20H2,1-2H3
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480756
PNG
(US10905687, Compound 9)
Show SMILES CCOC(=O)C1CN(Cc2ccncc2)CCN1Cc1ccc(cc1)-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H29F6N3O3/c1-2-41-26(39)25-19-37(17-21-11-13-36-14-12-21)15-16-38(25)18-20-3-5-22(6-4-20)23-7-9-24(10-8-23)27(40,28(30,31)32)29(33,34)35/h3-14,25,40H,2,15-19H2,1H3
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480775
PNG
(US10905687, Compound 51)
Show SMILES CCOCCOC(=O)C[C@H]1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C32H35F6N3O4/c1-2-44-17-18-45-29(42)19-28-22-40(15-16-41(28)21-24-11-13-39-14-12-24)20-23-3-5-25(6-4-23)26-7-9-27(10-8-26)30(43,31(33,34)35)32(36,37)38/h3-14,28,43H,2,15-22H2,1H3/t28-/m0/s1
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480773
PNG
(US10905687, Compound 49)
Show SMILES CCOC(=O)C[C@@H]1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C30H31F6N3O3/c1-2-42-27(40)17-26-20-38(15-16-39(26)19-22-11-13-37-14-12-22)18-21-3-5-23(6-4-21)24-7-9-25(10-8-24)28(41,29(31,32)33)30(34,35)36/h3-14,26,41H,2,15-20H2,1H3/t26-/m1/s1
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480757
PNG
(US10905687, Compound 10)
Show SMILES CCOC(=O)CC1CN(Cc2ccncc2)CCN1Cc1ccc(cc1)-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H31F6N3O3/c1-2-42-27(40)17-26-20-38(18-22-11-13-37-14-12-22)15-16-39(26)19-21-3-5-23(6-4-21)24-7-9-25(10-8-24)28(41,29(31,32)33)30(34,35)36/h3-14,26,41H,2,15-20H2,1H3
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480770
PNG
(US10905687, Compound 35)
Show SMILES CCOC(=O)CC1CN(Cc2ccc(c(C)c2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C31H33F6N3O3/c1-3-43-28(41)17-26-20-39(14-15-40(26)19-22-10-12-38-13-11-22)18-23-4-9-27(21(2)16-23)24-5-7-25(8-6-24)29(42,30(32,33)34)31(35,36)37/h4-13,16,26,42H,3,14-15,17-20H2,1-2H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480769
PNG
(US10905687, Compound 33)
Show SMILES NCCOC(=O)CC1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C30H32F6N4O3/c31-29(32,33)28(42,30(34,35)36)25-7-5-24(6-8-25)23-3-1-21(2-4-23)18-39-14-15-40(19-22-9-12-38-13-10-22)26(20-39)17-27(41)43-16-11-37/h1-10,12-13,26,42H,11,14-20,37H2
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n/an/a 5.50E+3n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480759
PNG
(US10905687, Compound 13)
Show SMILES OC(=O)CC1CN(Cc2ccncc2)CCN1Cc1ccc(cc1)-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C28H27F6N3O3/c29-27(30,31)26(40,28(32,33)34)23-7-5-22(6-8-23)21-3-1-19(2-4-21)17-37-14-13-36(18-24(37)15-25(38)39)16-20-9-11-35-12-10-20/h1-12,24,40H,13-18H2,(H,38,39)
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n/an/a 5.50E+3n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480765
PNG
(US10905687, Compound 28)
Show SMILES CC(C)NC(=O)C1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C30H32F6N4O2/c1-20(2)38-27(41)26-19-39(15-16-40(26)18-22-11-13-37-14-12-22)17-21-3-5-23(6-4-21)24-7-9-25(10-8-24)28(42,29(31,32)33)30(34,35)36/h3-14,20,26,42H,15-19H2,1-2H3,(H,38,41)
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480774
PNG
(US10905687, Compound 50)
Show SMILES Cc1cc(CN2CCN(Cc3ccncc3)[C@@H](CC(O)=O)C2)ccc1-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C29H29F6N3O3/c1-19-14-21(16-37-12-13-38(24(18-37)15-26(39)40)17-20-8-10-36-11-9-20)2-7-25(19)22-3-5-23(6-4-22)27(41,28(30,31)32)29(33,34)35/h2-11,14,24,41H,12-13,15-18H2,1H3,(H,39,40)/t24-/m0/s1
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480758
PNG
(US10905687, Compound 12)
Show SMILES OC(=O)C1CN(Cc2ccncc2)CCN1Cc1ccc(cc1)-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H25F6N3O3/c28-26(29,30)25(39,27(31,32)33)22-7-5-21(6-8-22)20-3-1-18(2-4-20)16-36-14-13-35(17-23(36)24(37)38)15-19-9-11-34-12-10-19/h1-12,23,39H,13-17H2,(H,37,38)
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480764
PNG
(US10905687, Compound 24)
Show SMILES CC(C)NC(=O)C1CN(Cc2ccncc2)CCN1Cc1ccc(cc1)-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H32F6N4O2/c1-20(2)38-27(41)26-19-39(17-22-11-13-37-14-12-22)15-16-40(26)18-21-3-5-23(6-4-21)24-7-9-25(10-8-24)28(42,29(31,32)33)30(34,35)36/h3-14,20,26,42H,15-19H2,1-2H3,(H,38,41)
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ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480763
PNG
(US10905687, Compound 21)
Show SMILES OC(=O)CC1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C28H27F6N3O3/c29-27(30,31)26(40,28(32,33)34)23-7-5-22(6-8-23)21-3-1-19(2-4-21)16-36-13-14-37(24(18-36)15-25(38)39)17-20-9-11-35-12-10-20/h1-12,24,40H,13-18H2,(H,38,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM480762
PNG
(US10905687, Compound 20)
Show SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)CCN1Cc1ccncc1
Show InChI InChI=1S/C27H25F6N3O3/c28-26(29,30)25(39,27(31,32)33)22-7-5-21(6-8-22)20-3-1-18(2-4-20)15-35-13-14-36(23(17-35)24(37)38)16-19-9-11-34-12-10-19/h1-12,23,39H,13-17H2,(H,37,38)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



ESCALIER BIOSCIENCES B.V.

US Patent


Assay Description
Human RORγ ligand binding assay was performed in 96-well format. The N-terminal DNA binding domains (DBD) of the native RORγ and RORγt...


US Patent US10905687 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%