Compile Data Set for Download or QSAR
maximum 50k data
Found 9 Enz. Inhib. hit(s) with all data for entry = 7942
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM50134248(Alpha-Hydroxy-Midazolam | CHEMBL1188 | US9333197, ...)
Affinity DataIC50:  2.70E+3nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.26%) are incubated with human liver microsome...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM224815(US9333197, 6beta Hydroxytestosterone)
Affinity DataIC50:  1.05E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.275%) are incubated with human liver microsom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM224023(Dextrorphan)
Affinity DataIC50:  1.77E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.25%) are incubated with human liver microsome...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2B6(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM224811(US9333197, Hydroxybupropion)
Affinity DataIC50:  1.92E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.3%) are incubated with human liver microsomes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C8(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM224812(US9333197, 6alpha-Hydroxypaclitaxel)
Affinity DataIC50:  2.16E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.3%) are incubated with human liver microsomes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM224814(US9333197, 4-Hydroxymephenytoin)
Affinity DataIC50: >2.50E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.25%) are incubated with human liver microsome...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM26197(CHEMBL112 | N-(4-hydroxyphenyl)acetamide | Norco |...)
Affinity DataIC50: >2.50E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.3%) are incubated with human liver microsomes...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetCytochrome P450 1A1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM195591(US9216974,Resorufin | US9333197, Resorufin)
Affinity DataIC50: >2.50E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.3%) are incubated with human liver microsomes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM224813(US9333197, 4-Hydroxytolbutamide)
Affinity DataIC50: >2.50E+4nMAssay Description:Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.25%) are incubated with human liver microsome...More data for this Ligand-Target Pair
In DepthDetails US Patent