Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 1805
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 12 | US9765057, 16 | me...)
Affinity DataIC50:  5.46nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341072(Benzyl trans-5-hydroxy-2-methylpiperidine-1-carbox...)
Affinity DataIC50:  8.30nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341136(US9765057, 3 | US9975876, 1 | methyl 4-(methylsulf...)
Affinity DataIC50:  10nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341135(US9765057, 15 | US9765057, 2 | methyl 4-methy1-2-{...)
Affinity DataIC50:  17.4nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341143(Methyl 4-ethyl-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,...)
Affinity DataIC50:  21.1nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341137(US9765057, 4)
Affinity DataIC50:  28.3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341139(US9765057, 6 | methyl 2-({(3R,6R)-1-[(4-fluoro-2- ...)
Affinity DataIC50:  31.6nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341141(Methyl 4-azetidin-1-yl-2-{[(3R,6R)-6-methyl-1-{[2-...)
Affinity DataIC50:  33nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341135(US9765057, 15 | US9765057, 2 | methyl 4-methy1-2-{...)
Affinity DataIC50:  36.2nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341140(US9765057, 7 | methyl 2-({(3R,6R)-1-[(3-fluoro-2- ...)
Affinity DataIC50:  37.8nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341150(Ethyl 4-ethyl-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...)
Affinity DataIC50:  40.4nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 12 | US9765057, 16 | me...)
Affinity DataIC50:  68.8nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341138(US9765057, 5 | methyl 2-({(3R,6R)-1-[(5-fluoro-2- ...)
Affinity DataIC50:  72.9nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341143(Methyl 4-ethyl-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,...)
Affinity DataIC50:  74.9nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341072(Benzyl trans-5-hydroxy-2-methylpiperidine-1-carbox...)
Affinity DataIC50:  79nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 12 | US9765057, 16 | me...)
Affinity DataIC50:  80nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341135(US9765057, 15 | US9765057, 2 | methyl 4-methy1-2-{...)
Affinity DataIC50:  86.2nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341150(Ethyl 4-ethyl-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3...)
Affinity DataIC50:  172nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341147(US9765057, 14 | methyl 4-cyclobutyl-2-{[(3R,6R)-6-...)
Affinity DataIC50:  272nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341146(US9765057, 13 | methyl 4-cyclopropyl-2-{[(3R,6R)-6...)
Affinity DataIC50:  530nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341137(US9765057, 4)
Affinity DataIC50:  554nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341136(US9765057, 3 | US9975876, 1 | methyl 4-(methylsulf...)
Affinity DataIC50:  618nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341141(Methyl 4-azetidin-1-yl-2-{[(3R,6R)-6-methyl-1-{[2-...)
Affinity DataIC50:  743nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341146(US9765057, 13 | methyl 4-cyclopropyl-2-{[(3R,6R)-6...)
Affinity DataIC50:  803nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341138(US9765057, 5 | methyl 2-({(3R,6R)-1-[(5-fluoro-2- ...)
Affinity DataIC50:  880nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341139(US9765057, 6 | methyl 2-({(3R,6R)-1-[(4-fluoro-2- ...)
Affinity DataIC50:  888nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 12 | US9765057, 16 | me...)
Affinity DataIC50:  1.01E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341140(US9765057, 7 | methyl 2-({(3R,6R)-1-[(3-fluoro-2- ...)
Affinity DataIC50:  1.03E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 12 | US9765057, 16 | me...)
Affinity DataIC50:  1.46E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341142(US9765057, 9 | methyl 4-(4-methylpiperazin-1-yl)- ...)
Affinity DataIC50:  1.53E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341135(US9765057, 15 | US9765057, 2 | methyl 4-methy1-2-{...)
Affinity DataIC50:  1.93E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341144(US9765057, 11 | US9765057, 12 | US9765057, 16 | me...)
Affinity DataIC50:  2.05E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341147(US9765057, 14 | methyl 4-cyclobutyl-2-{[(3R,6R)-6-...)
Affinity DataIC50:  5.58E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341142(US9765057, 9 | methyl 4-(4-methylpiperazin-1-yl)- ...)
Affinity DataIC50:  1.00E+4nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent